Drug-Enhanced Unclogging Motions of a Double Helical Magnetic Micromachine for Occlusive Vascular Diseases
Drug-Enhanced Unclogging Motions of a Double Helical Magnetic Micromachine for Occlusive Vascular Diseases
复制标题
双螺旋磁微机械的药物增强疏通运动治疗闭塞性血管疾病
DOI：
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发表时间：
2014
影响因子：
2.1
通讯作者：
Wonseo Lee
中科院分区：
文献类型：
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作者：
S. Jeon;G. Jang;Wonseo Lee
我们提出了一种新的双螺旋磁微机械（DHMM），以实现药物增强疏通能力的闭塞性血管疾病（OVD）在人体血管。建议DHMM可以产生导航和机械钻井运动驱动的外部旋转磁场（ERMF）。它还可以将血栓破坏药物输送到目标点（堵塞区域），并可以精确地向堵塞区域释放药物。我们推导出旋转动力学约束方程的选择性操纵的导航，药物释放，和机械钻孔运动的DHMM通过控制ERMF。然后，我们原型的DHMM和演示这些运动，以显示所提出的DHMM和操作方法的有效性。
We propose a novel double helical magnetic micromachine (DHMM) to achieve drug-enhanced unclogging abilities for occlusive vascular diseases (OVDs) in human blood vessels. The proposed DHMM can generate navigating and mechanical drilling motions actuated by an external rotating magnetic field (ERMF). It can also deliver a clot-busting drug to a target point (clogged area) and can precisely release the drug toward the clogged area. We derive rotational dynamic constraint equations for selective manipulation of the navigating, drug releasing, and mechanical drilling motions of the DHMM by controlling the ERMF. We then prototype the DHMM and demonstrate these motions to show the validity of the proposed DHMM and manipulation methods.