Underlying neurological mechanisms associated with symptomatic convergence insufficiency.
Underlying neurological mechanisms associated with symptomatic convergence insufficiency.
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DOI：
10.1038/s41598-021-86171-9
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发表时间：
2021-03-22
影响因子：
4.6
通讯作者：
Biswal BB
中科院分区：
文献类型：
--
作者：
Alvarez TL;Scheiman M;Morales C;Gohel S;Sangoi A;Santos EM;Yaramothu C;d'Antonio-Bertagnolli JV;Li X;Biswal BB
会聚不足（CI）是最常见的双眼视觉问题，与模糊/复视、头痛和眼睛疼痛相关，当进行长时间的近距离工作（例如阅读）时会加剧。会聚功能不全神经机制成人人群研究（NCT 03593031）通过检查快速和慢速融合视差聚散系统，研究了50例双眼正常对照（BNC）和50例症状性CI参与者之间的神经机制差异。对快速融合系统进行预编程，并使用会聚峰值速度进行评估。缓慢融合系统优化了聚散努力，并通过测量隐斜视适应幅度和速率进行评估。对于快速融合系统，BNC和CI组之间的会聚峰值速度，最终位置振幅，和功能成像活动的次级视觉皮层，右楔，和眼蚓部观察到显着差异。对于慢融合系统，隐斜视适应的幅度和速率，以及内侧楔功能活动，组间有显著差异。在聚散峰值速度和右楔功能活动（p = 0.002）以及隐斜视适应率和内侧楔功能活动（p = 0.02）之间观察到显著相关性。这些结果描绘了大脑的聚散行为。未来的治疗干预可能会考虑实施程序，增加楔活动，这种衰弱的疾病。
Convergence insufficiency (CI) is the most common binocular vision problem, associated with blurred/double vision, headaches, and sore eyes that are exacerbated when doing prolonged near work, such as reading. The Convergence Insufficiency Neuro-mechanism Adult Population Study (NCT03593031) investigates the mechanistic neural differences between 50 binocularly normal controls (BNC) and 50 symptomatic CI participants by examining the fast and slow fusional disparity vergence systems. The fast fusional system is preprogrammed and is assessed with convergence peak velocity. The slow fusional system optimizes vergence effort and is assessed by measuring the phoria adaptation magnitude and rate. For the fast fusional system, significant differences are observed between the BNC and CI groups for convergence peak velocity, final position amplitude, and functional imaging activity within the secondary visual cortex, right cuneus, and oculomotor vermis. For the slow fusional system, the phoria adaptation magnitude and rate, and the medial cuneus functional activity, are significantly different between the groups. Significant correlations are observed between vergence peak velocity and right cuneus functional activity (p = 0.002) and the rate of phoria adaptation and medial cuneus functional activity (p = 0.02). These results map the brain-behavior of vergence. Future therapeutic interventions may consider implementing procedures that increase cuneus activity for this debilitating disorder.
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影响因子：
3.5
作者：
Alvarez TL;Jaswal R;Gohel S;Biswal BB
通讯作者：
Biswal BB
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1.4
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通讯作者：
Albert, J.
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