Concomitant or Sequential Therapy as the First-line Therapy for Eradication of Helicobacter pylori Infection in Korea: A Systematic Review and Meta-analysis.
Concomitant or Sequential Therapy as the First-line Therapy for Eradication of Helicobacter pylori Infection in Korea: A Systematic Review and Meta-analysis.
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DOI：
10.4166/kjg.2018.71.1.31
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发表时间：
2018-01-25
影响因子：
--
通讯作者：
Nam, Yun Jung
中科院分区：
文献类型：
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作者：
Bae, Hyun Jin;Kim, Joon Sung;Nam, Yun Jung
背景/目的：在韩国，克拉霉素耐药性的增加导致需要替代一线疗法来根除幽门螺杆菌（H. pylori）感染。联合治疗（CT）和序贯治疗（ST）已被提议作为替代方案。本研究的目的是比较韩国使用 CT 和 ST 的根除率。方法：对比较韩国 CT 和 ST 疗效的研究进行文献综述。汇总数据以获得根除率的比值比 (OR)，置信区间 (CI) 为 95%。根除率根据意向治疗 (ITT) 和符合方案 (PP) 进行考虑。结果：六项研究提供了 1,897 名韩国成年患者的数据。 ITT 分析的汇总 OR 为 1.382（95% CI：1.031-1.853，p=0.031），ITT 分析的汇总 OR 为 2.114（95% CI：1.502-2.974，p=0.031）
Background/Aims: In Korea, increasing clarithromycin resistance has led to the need for an alternative first-line therapy for the eradication of Helicobacter pylori (H. pylori) infection. Concomitant therapy (CT) and sequential therapy (ST) have been proposed as alternative regimens. The aim of this study was to compare the eradication rate from using CT and ST in Korea.Methods: A literature review was performed on studies comparing the efficacy of CT and ST in Korea. Data were pooled to obtain the odds ratio (OR) of the eradication rate with 95% confidence intervals (CIs). The eradication rates were considered both on an intention-to-treat (ITT) and a per-protocol (PP) bases.Results: Six studies provided data on 1,897 Korean adult patients. The pooled OR was 1.382 (95% CI: 1.031-1.853, p=0.031) for ITT analysis and 2.114 (95% CI: 1.502-2.974, p