The effect of micronutrient supplementation on disease progression and death in simian immunodeficiency virus-infected juvenile male rhesus macaques.
The effect of micronutrient supplementation on disease progression and death in simian immunodeficiency virus-infected juvenile male rhesus macaques.
复制标题
微量营养素补充对感染猿猴免疫缺陷病毒的幼年雄性恒河猴疾病进展和死亡的影响。
DOI：
10.1086/430951
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Gorbach,SherwoodL
中科院分区：
文献类型：
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作者：
Goldin,BarryR;Li,Wenjun;Mansfield,Keith;Woods,Margo;Wanke,Christine;Freeman,Lisa;Shevitz,Abby;Gualtieri,Lisa;Bussell,Sarah;Gorbach,SherwoodL
背景我们研究了微量营养素补充对猴获得性免疫缺陷综合征（SAIDS）进展的影响。方法24只感染猴免疫缺陷病毒的幼年雄性恒河猴随机分为2组。其中一组被给予经过认证的食物，另一组被给予食物和含有2-3倍于估计的微量营养素营养需求的补充剂。每4周进行一次病毒学、免疫学和身体成分测量，持续120周。结果两组在体重增加、体重指数（BMI）、冠踵长度、腰围、总组织质量、瘦体重、骨矿物质含量或骨矿物质密度方面没有差异。补充饲料的恒河猴的死亡率（风险比，2.39; P<0.001）高于未补充饲料的恒河猴;两组的死亡均与感染早期较高的病毒载量设定点相关。此外，在两组中，较高的体重、BMI、顶臀长度和较低的病毒载量设定点对死亡具有保护作用。结论补充营养素并没有显著改变SAIDS在身体成分和免疫学特征方面的进展。一个显着更高的死亡率观察恒河猴的补充饮食
BackgroundWe investigated the impact that micronutrient supplementation has on the progression of simian acquired immunodeficiency syndrome (SAIDS)MethodsTwenty-four simian immunodeficiency virus–infected juvenile male rhesus macaques were randomized into 2 groups. One group was given certified chow, and the other group was given chow and a supplement that contained 2–3 times the estimated nutritional requirement of micronutrients. Virological, immunological, and body composition measurements were taken every 4 weeks for 120 weeksResultsThere was no difference between groups in weight gain, body mass index (BMI), crown-heel length, waist circumference, total tissue mass, lean mass, bone mineral content, or bone mineral density. The rhesus macaques on the supplemented diet had a higher death rate (hazard ratio, 2.39; P<.001) than those on the nonsupplemented diet; death in both groups was associated with a higher viral load set point during the early phase of infection. Additionally, higher body weight, BMI, crown-rump length, and lower viral load set point were protective from death in both groupsConclusionsMicronutrient supplementation did not significantly alter the progression of SAIDS with respect to changes in body composition and immunological characteristics. A significantly higher rate of death was observed in rhesus macaques on the supplemented diet