The ubiquitin-binding protein p62 is expressed in breast cancers showing features of aggressive disease
The ubiquitin-binding protein p62 is expressed in breast cancers showing features of aggressive disease
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DOI：
10.1677/erc.1.01312
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发表时间：
2007-03-01
影响因子：
3.9
通讯作者：
Spendlove, Ian
中科院分区：
文献类型：
--
作者：
Rolland, Phil;Madjd, Zahra;Spendlove, Ian
p62是一种多功能蛋白，通过多种上游信号通路诱导核因子κ B （NF κ B）激活，包括表皮生长因子（EGF）受体家族触发的信号通路。我们假设p62过表达增加EGF家族受体表达与乳腺癌预后恶化相关。我们使用商业豚鼠抗人p62血清和标准免疫组织化学方法对代表523例乳腺癌的组织微阵列进行染色来解决这个问题。在106个肿瘤中，20.3%呈阳性染色。p62表达与肿瘤分级（P = 0.010）、远处转移（P = 0.04）、EGF受体（EGFR） （P = 0.012）、HER2 （P = 0.016）、HER3 （P = 0.007）、HER4（0.002）表达相关。尽管表达与5年生存率降低相关（58.5 vs 73.6%），但与总体疾病特异性生存率无相关性。p62的表达可能是NF κ B通路激活的标志。
p62 is a multi-functional protein, which induces nuclear factor-kappa B (NF kappa B) activation through multiple upstream signalling pathways, including those triggered by the epidermal growth factor (EGF) family of receptors. We hypothesised that p62 overexpression increased EGF family receptor expression and worse outcome in breast cancer would be associated. We stained a tissue microarray representing 523 breast cancers using a commercial guinea pig anti-human p62 sera and standard immunohistochemical methods to address this. Out of n= 106 tumours, 20.3% stained positively. p62 expression correlated with grade (P = 0.010) and distant metastasis (P = 0.04) and EGF receptor (EGFR) (P = 0.012), HER2 (P = 0.016), HER3 (P = 0.007) and HER4 (0.002) expressions. Though expression correlated with reduced 5-year survival (58.5 vs 73.6%), there was no association with overall disease specific survival. p62 expression may represent a marker of activation of the NF kappa B pathway.