DETECTING PULMONARY EDEMA THROUGHOUT EX VIVO LUNG PERFUSION
DETECTING PULMONARY EDEMA THROUGHOUT EX VIVO LUNG PERFUSION
复制标题
通过离体肺灌注检测肺水肿
DOI：
10.1115/dmd2023-4133
复制
发表时间：
2023
期刊：
影响因子：
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通讯作者：
Iaizzo, Paul A.
中科院分区：
文献类型：
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作者：
Nadybal, Ryan;Wang, Andrew;Iaizzo, Paul A.
离体肺灌注（EVLP）现在是一种强大的临床技术，促进了成功的人类肺移植手术的增加。通过具有评估边缘肺、延长保存时间和扩大捐赠地理距离的能力，EVLP有效地扩大了人类肺移植供体库并缩短了移植等待名单上的时间。虽然临床使用已经扩大，但EVLP的临床前研究还没有。EVLP可用作临床前研究模型，即，为了研究药理学反应（例如，后调节剂）、器官保存、装置测试和/或方法学开发。为了方便使用EVLP作为研究工具，我们开发了一种低成本的测试系统，其功能不断增加，例如，使用新型连续重量传感器评估肺水肿。对水肿的真实的时间跟踪使我们能够深入了解肺损伤的潜在原因，并研究在短时间内（<8小时）恢复和减轻损伤的技术。该系统增强了我们准确测试医疗设备、肺部生理学和对肺部的潜在治疗影响的能力。
Ex Vivo Lung Perfusion (EVLP) is now a powerful clinical technique that has facilitated the increase in successful human lung transplantation procedures. By having the abilities to assess marginal lungs, extend preservation times, and expand geographical distances for donations, EVLP has effectively both expanded the human lung transplantation donor pool and shortened times on the transplant waitlist. While clinical usage has expanded, preclinical research on EVLP has not. EVLP can be utilized as a preclinical research model, i.e., to investigate pharmacological responses (e.g., post-conditioning agents), organ preservation, device testing and/or methodology development. To facilitate the use of EVLP as a research tool, we have developed a low-cost testing system with ever increasing capabilities e.g., the use of a novel continuous weight sensor to evaluate lung edema. Real time tracking of edema allows us to hone in on potential causes of lung damage, and investigate techniques to rehabilitate and mitigate damage on a short time scale (<8 hours). This system enhances our abilities to accurately test medical devices, lung physiology, and potential treatment impacts on lungs.