A new animal model of femoral head necrosis induced by intraosseous injection of ethanol
A new animal model of femoral head necrosis induced by intraosseous injection of ethanol
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DOI：
10.1258/0023677021912460
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发表时间：
2002-04-01
影响因子：
2.4
通讯作者：
Simank, HG
中科院分区：
文献类型：
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作者：
Manggold, J;Sergi, C;Simank, HG
目前尚无可靠的早期股骨头坏死动物模型来评价新的治疗方法。在本研究中，我们提出了一种新的股骨头坏死动物模型。成年美利奴绵羊在透视控制下股骨头中央注射无水乙醇。3、6、12周后处死动物，取股骨头。分析和记录显微放射学改变和组织学改变。在12周的时间里，所有动物都有部分坏死的记录。坏死的外观与完整的大体结构、大循环和关节软骨相似，与人类早期ONFH的特征相似。由于其有效性和与人类ONFH早期阶段的相似性，该模型可能适合于评估治疗ONFH的新治疗技术。
There is no reliable animal model of the early stages of osteonecrosis of the femoral head (ONFH) for the evaluation of new therapeutic approaches. In this study, we propose a new animal model of femoral head osteonecrosis. Pure ethanol was injected into the centre of the femoral head in adult Merino sheep under fluoroscopic control. After 3, 6 and 12 weeks the animals were killed and the femoral heads were harvested. Microradiographic and histological changes were analysed and recorded. Partial necrosis was documented over a period of 12 weeks in all animals. The appearance of necrosis in combination with intact macrotexture, macrocirculation and joint cartilage is similar to the features described in early ONFH in humans. Due to its efficacy and its similarity to the early stages of ONFH in humans, this model may be suitable to evaluate new therapeutic techniques in the treatment of ONFH.