Synthesis of novel carbazole based macrocyclic amides as potential antimicrobial agents.
Synthesis of novel carbazole based macrocyclic amides as potential antimicrobial agents.
复制标题
DOI：
10.1016/j.ejmech.2008.07.031
复制
发表时间：
2009-07
影响因子：
6.7
通讯作者：
P. Rajakumar;Karuppannan Sekar;V. Shanmugaiah;N. Mathivanan
中科院分区：
文献类型：
--
作者：
P. Rajakumar;Karuppannan Sekar;V. Shanmugaiah;N. Mathivanan
合成了一系列具有硫杂和氧键的咔唑基大环二酰胺，并记录了环芳酰胺对人类病原细菌和植物病原真菌的抑制活性。 (S)-1,10-Bi-2-萘酚 [(S)-BINOL] 基手性咔唑并酰胺成为该系列中最有趣的化合物，具有优异的抗菌和抗真菌活性。
A series of carbazole based macrocyclic diamides with thia and oxy linkages have been synthesized and the inhibitory activity of the cyclophane amides against human pathogenic bacteria and plant pathogenic fungi are documented. (S)-1,10-Bi-2-naphthol [(S)-BINOL] based chiral carbazolophane amide emerged as the most interesting compound in this series exhibiting excellent antibacterial and antifungal activities.