Sex-related difference in food-anticipatory activity of mice
Sex-related difference in food-anticipatory activity of mice
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DOI：
10.1016/j.yhbeh.2015.02.004
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发表时间：
2015-04-01
影响因子：
3.5
通讯作者：
Wang, Jundong
中科院分区：
文献类型：
--
作者：
Li, Zhigang;Wang, Yan;Wang, Jundong
食物预期活动（FAA）的表达是由限制性摄食（RF）诱导的，其夹带需要食物可消化的振荡器，其神经解剖学基础目前尚不清楚。虽然RF影响各种激素，但FAA中与性别相关的差异尚不清楚。“在这里，我们报告了在RF期间雄性小鼠比雌性小鼠明显更多的食物预期轮运行活动。与性别相关的FAA差异平行，雄性和雌性小鼠对RF的反应显示出不同的食物摄入量和体重。由于性腺激素可能参与FAA的性别特异性差异，我们比较了假手术和性腺切除的雄性和雌性野生型小鼠。在性腺切除小鼠，性别差异在FAA被取消，表明性腺激素在FAA的作用。此外，血浆中的激素生长激素释放肽的浓度在雌性小鼠比雄性小鼠在随意（AL）喂养，和RF诱导的时间提前在两种性别的峰值。RF也改变了海马和肝脏中的昼夜节律基因mPer1的表达峰值，尽管在其表达的水平或周期阶段中没有发现性别差异。Per1（Brdm1）突变小鼠的FAA仍然具有性二态性，但在雄性和雌性Per2（Brdm1）突变小鼠中均观察到FAA减少。总之，我们的研究结果表明，性腺激素有助于FAA的性别差异，可能通过调节生长激素释放肽的活性。(C)由Elsevier Inc.出版。
The expression of food-anticipatory activity (FAA) is induced by restricted feeding (RF), and its entrainment requires food-entrainable oscillators, the neuroanatomical basis of which is currently unclear. Although RF impacts various hormones, sex-related differences in FAA are unclear. 'Here, we report significantly more food-anticipatory wheel-running activity in male than in female mice during RF. In parallel with the sex-related difference in FAA, male and female mice display different food intake and body weight in response to RF. Since gonadal hormones could be involved in the sex-specific difference in FAA, we compared sham and gonadectomized male and female wild-type mice. In gonadectomized mice, the sex difference in FAA was abolished, indicating a role for gonadal hormones in FAA. Further, plasma concentrations of the hormone ghrelin were higher in female than in male mice during ad libitum (AL) feeding, and RF induced a temporal advance in its peak in both sexes. RF also shifted the expression peak of the circadian gene mPer1 in the hippocampus and liver, although no sex difference was found in either the level or the cyclic phase of its expression. Per1(Brdm1) mutant mice were still sexually dimorphic for FAA, but diminished FAA was noted in both male and female Per2(Brdm1) mutant mice. In summary, our results imply that gonadal hormones contribute to the sex difference in FAA, possibly through modulating ghrelin activity. (C) 2015 Published by Elsevier Inc.