Nasal inhalation of budesonide from a spacer in children with perennial rhinitis and asthma
Nasal inhalation of budesonide from a spacer in children with perennial rhinitis and asthma
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DOI：
10.1111/j.1398-9995.1998.tb03909.x
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发表时间：
1998-04-01
期刊：
影响因子：
12.4
通讯作者：
Mygind, N
中科院分区：
文献类型：
--
作者：
Pedersen, W;Hjuler, I;Mygind, N
过敏性鼻炎和哮喘的标准治疗包括局部皮质类固醇鼻内给药和经口吸入。虽然这种疗法是非常有效的，并且副作用很少且轻微，但有可能进一步改善治疗指数和患者对治疗的依从性。在本研究中，我们评估了鼻吸入系统用于鼻炎和哮喘的同时治疗。原则上，它导致皮质类固醇的气道沉积类似于吸入性过敏原。在一项双盲、安慰剂对照、交叉研究中，24名患有常年性鼻炎和哮喘的儿童通过鼻吸入加压气雾剂中的布地奈德，气雾剂连接到一个间隔装置上。与安慰剂相比，布地奈德治疗导致鼻部症状显著减轻（P
The standard treatment of allergic rhinitis and asthma consists of topical corticosteroids administered intranasally and inhaled through the mouth. Although this therapy is highly effective, and side-effects are few and mild, it may be possible further to improve the therapeutic index and patient compliance with the treatment. In the present study, we evaluated a nasal inhalation system used for the simultaneous treatment of rhinitis and asthma. In principle, it results in an airway deposition of the corticosteroid similar to that of inhaled allergens. Twenty-four children with perennial rhinitis and asthma inhaled budesonide through the nose from a pressurized aerosol, attached to a spacer device, in a double-blind, placebo-controlled, crossover study. Compared with placebo, budesonide treatment resulted in a significant reduction of nasal symptoms (P