Association of Human Papillomavirus Genotype 16 Viral Variant and Viral Load with Cervical High-grade Intraepithelial Lesions
Association of Human Papillomavirus Genotype 16 Viral Variant and Viral Load with Cervical High-grade Intraepithelial Lesions
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人乳头瘤病毒基因型 16 病毒变异体和病毒载量与宫颈高级上皮内病变的关联
DOI：
10.1158/1940-6207.capr-18-0397
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发表时间：
2018
影响因子：
3.3
通讯作者：
María Paz
中科院分区：
文献类型：
--
作者：
Ledicia Álvarez;M. Santibáñez;A. Galiana;J. C. Rodríguez Díaz;P. Parás;Mª Encarnación Andrada;María Montserrat Ruiz García;José María Rodríguez;J. Portilla;María Paz
人类乳头瘤病毒基因型16 （HPV16）是迄今为止与宫颈癌最密切相关的基因型；HPV16的病毒变异和/或病毒载量可以调节这种关联。目的是确定HPV16的病毒变异和病毒载量与宫颈高级别病变之间的关系。这项横断面研究包括在常规妇科健康检查中通过宫颈涂片发现HPV感染的所有妇女。选择单次或多次HPV16感染的妇女（n = 176）进行病毒变异和病毒载量分析。使用Bethesda系统对涂片结果进行分类。HPV类型是根据国际癌症研究机构进行分类的。比值比（OR）及其95%置信区间（CI）通过逻辑回归进行估计，并根据年龄、移民身份和与其他高危基因型的合并感染进行调整。在检测到的病毒变异方面没有发现统计学上显著的关联。在调整了年龄、移民身份、合并感染和病毒变异等因素后，高于中位数（1,367.79拷贝/细胞）的病毒载量与高级别上皮病变或癌的显著风险相关（调整or为7.89;95% CI: 2.75-22.68）。按病毒载量三分位数分类后，这种关系显示出具有统计学意义的剂量-反应模式：病毒载量大于第三分位数的调整OR为17.23 (95% CI: 4.20-70.65)，调整线性p趋势= 0.001。在感染HPV16的患者中，病毒载量与高级别上皮内病变或宫颈癌相关。这可以作为肿瘤进展的预后生物标志物和宫颈癌的筛查。
Human papillomavirus genotype 16 (HPV16) is by far the genotype most strongly associated with cervical cancer; viral variant and/or viral load of HPV16 could modulate this association. The objective was to determine the association between the viral variant and viral load of HPV16 and the presence of cervical high-grade lesions. This cross-sectional study included all women in whom HPV infection was found by cervical smear during routine gynecologic health checks. Women with single or multiple HPV16 infections (n = 176) were selected for viral variant and viral load analysis. Smear results were classified using the Bethesda system. HPV types were classified according to the International Agency for Research on Cancer. Odds ratios (OR) with their 95% confidence intervals (CI) were estimated by logistic regression, adjusted for age, immigrant status, and coinfection with other high-risk genotypes. No statistically significant associations were found regarding the detected viral variants. A viral load above the median (>1,367.79 copies/cell) was associated with a significant risk of high-grade epithelial lesion or carcinoma, after adjusting for age, immigrant status, coinfections, and viral variant: (adjusted OR 7.89; 95% CI: 2.75–22.68). This relationship showed a statistically significant dose–response pattern after categorizing by viral load tertiles: adjusted OR for a viral load greater than the third tertile was 17.23 (95% CI: 4.20–70.65), with adjusted linear Ptrend = 0.001. In patients infected with HPV16, viral load is associated with high-grade intraepithelial lesions or cervical carcinoma. This could be useful as prognostic biomarker of neoplastic progression and as screening for cervical cancer.
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DOI：
10.1093/jnci/94.2.102
发表时间：
2002-01-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Sherman, ME;Schiffman, M;Cox, JT
通讯作者：
Cox, JT
影响因子：
6.4
作者：
Xi, Long Fu;Hughes, James P.;Schiffman, Mark
通讯作者：
Schiffman, Mark
影响因子：
6.4
作者：
Plummer, Martyn;Schiffman, Mark;Wheeler, Cosette M.
通讯作者：
Wheeler, Cosette M.
影响因子：
11.2
作者：
Schiffman M;Rodriguez AC;Chen Z;Wacholder S;Herrero R;Hildesheim A;Desalle R;Befano B;Yu K;Safaeian M;Sherman ME;Morales J;Guillen D;Alfaro M;Hutchinson M;Solomon D;Castle PE;Burk RD
通讯作者：
Burk RD