Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic.
Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic.
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DOI：
10.1080/22221751.2021.1898291
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发表时间：
2021-12
影响因子：
13.2
通讯作者：
Yuen KY
中科院分区：
文献类型：
--
作者：
To KK;Sridhar S;Chiu KH;Hung DL;Li X;Hung IF;Tam AR;Chung TW;Chan JF;Zhang AJ;Cheng VC;Yuen KY
如果没有现代医疗管理和疫苗，由严重急性呼吸系统综合征（SARS）冠状病毒2（SARS-CoV-2）引起的2019年冠状病毒病（COVID-19）大流行的严重程度可能接近1894年鼠疫（1200万人死亡）和1918年甲型H1N1流感（5000万人死亡）大流行的程度。2003年的SARS疫情预示了COVID-19大流行，该疫情导致发现了人类和果子狸SARS-CoV-1、蝙蝠SARS相关CoV、中东呼吸综合征（MERS）相关蝙蝠CoV HKU 4和HKU 5以及其他新型动物冠状病毒。包括人类冠状病毒OC 43（1890）、SARS-CoV-1（2003）、MERS-CoV（2012）和SARS-CoV-2（2019）在内的4种β冠状病毒疑似从动物跳到人类，表明它们具有重大的大流行潜力。蝙蝠和其他野生哺乳动物体内存在大量的冠状病毒，在卫生条件不佳的城市市场上混合和销售它们的文化，在人口稠密地区食用外来哺乳动物的习惯，以及来自这些地区的快速和频繁的空中旅行，都是酿造迅速爆发的流行病的完美成分。不应忽视从动物或实验室中出现假设的SARS-CoV-3或其他新型病毒的可能性，因此不应忽视全球防范的必要性。我们回顾了截至2021年1月20日（即宣布SARS-CoV-2人际传播一年后）有关COVID-19的流行病学、病毒学、临床表现、病理学、实验室诊断、治疗、疫苗接种和感染控制的代表性出版物。大规模检测的困难，劳动密集型接触者追踪，遵守普遍掩蔽的重要性，抗病毒治疗对严重疾病的低效率，疫苗或抗病毒药物耐药病毒变异的可能性和SARS-CoV-2成为另一种常见的感冒冠状病毒进行了讨论。
Without modern medical management and vaccines, the severity of the Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) might approach the magnitude of 1894-plague (12 million deaths) and 1918-A(H1N1) influenza (50 million deaths) pandemics. The COVID-19 pandemic was heralded by the 2003 SARS epidemic which led to the discovery of human and civet SARS-CoV-1, bat SARS-related-CoVs, Middle East respiratory syndrome (MERS)-related bat CoV HKU4 and HKU5, and other novel animal coronaviruses. The suspected animal-to-human jumping of 4 betacoronaviruses including the human coronaviruses OC43(1890), SARS-CoV-1(2003), MERS-CoV(2012), and SARS-CoV-2(2019) indicates their significant pandemic potential. The presence of a large reservoir of coronaviruses in bats and other wild mammals, culture of mixing and selling them in urban markets with suboptimal hygiene, habit of eating exotic mammals in highly populated areas, and the rapid and frequent air travels from these areas are perfect ingredients for brewing rapidly exploding epidemics. The possibility of emergence of a hypothetical SARS-CoV-3 or other novel viruses from animals or laboratories, and therefore needs for global preparedness should not be ignored. We reviewed representative publications on the epidemiology, virology, clinical manifestations, pathology, laboratory diagnostics, treatment, vaccination, and infection control of COVID-19 as of 20 January 2021, which is 1 year after person-to-person transmission of SARS-CoV-2 was announced. The difficulties of mass testing, labour-intensive contact tracing, importance of compliance to universal masking, low efficacy of antiviral treatment for severe disease, possibilities of vaccine or antiviral-resistant virus variants and SARS-CoV-2 becoming another common cold coronavirus are discussed.
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影响因子：
2.9
作者：
Cao Y;Hiyoshi A;Montgomery S
通讯作者：
Montgomery S
影响因子：
13.6
作者：
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影响因子：
158.5
作者：
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通讯作者：
Jonigk, Danny
影响因子：
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作者：
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Hernandez MB
影响因子：
4.4
作者：
Bestle, Dorothea;Heindl, Miriam Ruth;Boettcher-Friebertshaeuser, Eva
通讯作者：
Boettcher-Friebertshaeuser, Eva