A multivariate analysis of adhesion molecules expression in assessment of colorectal cancer
A multivariate analysis of adhesion molecules expression in assessment of colorectal cancer
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DOI：
10.1002/jso.20638
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发表时间：
2007-06-15
影响因子：
2.5
通讯作者：
Monden, Morito
中科院分区：
文献类型：
--
作者：
Ngan, Chew Yee;Yamamoto, Hirofumi;Monden, Morito
背景与目的：黏附分子与结直肠癌的发生发展密切相关。尽管有证据表明它们的表达与患者的预后有关，但这些数据并没有在同一项研究中同时进行检查；因此，相对的临床价值仍然很大程度上是未知的。本研究的目的是确定对结直肠癌患者具有最显著预后价值的粘连因素，以指导临床对适当治疗的决策。患者和方法：采用免疫组织化学方法检测140例中期II期和III期大肠癌组织中E-粘附素及其相关连环蛋白、α(α)-连环蛋白和β(β)-连环蛋白、DCC和CD44及其伴侣MT1-MMP的表达，以确定其预后意义。单因素和多因素分析显示E-钙粘素和CD44的表达缺失与患者的生存不良密切相关，尤其是在II期。联合研究表明，E-钙粘素和CD44的缺失对患者预后的影响最大，尤其是在结肠癌中。结论：E-钙粘素和CD44的免疫组织化学染色有助于识别高危的11期结直肠癌患者，特别是在结肠癌中，可能需要加强随访和采取适当的治疗策略。
Background and Objectives: Adhesion molecules are implicated in the progression of colorectal cancer (CRC). Despite the evidence of association between their expression and patients' prognosis, the data have not been examined simultaneously in a same study; thus, the relative clinical value remained largely unknown. The aim of this study was to identify the adhesion factors that display the most significant prognostic value for CRC patients to guide clinical decision-making regarding appropriate treatment. Patients andMethods: We examined by immunohistochemistry, the expression of E-adherin and its associated catenins, alpha((alpha)-catenin and beta(beta)-catenin, DCC, and CD44 and its partner, MT1-MMP in a series of 140 CRC tissues at intermediate Stage II and Stage III to determine their prognostic significance.Results: Clinicopathological survey indicated an inverse relationship between E-cadherin expression and tumor differentiation, and an association between CD44 expression and venous invasion. Univariate and multivariate analyses showed that loss of expression of E-cadherin and CD44 significantly correlated to poor survival, especially in Stage II. Combination studies indicated that loss of E-cadherin and loss of CD44 had the worst impact on patient prognosis, particularly in colon cancer.Conclusion: Immunohistochemical staining of E-cadherin and CD44 may help to identify a subgroup of high-risk patients with Stage 11 CRC, especially in colon cancer, who may need intensive follow-up and appropriate therapeutic strategy.