A mother's sacrifice: what is she keeping for herself?
A mother's sacrifice: what is she keeping for herself?
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DOI：
10.1016/j.ceb.2008.09.004
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发表时间：
2008-12-01
影响因子：
7.5
通讯作者：
Gottschling, Daniel E.
中科院分区：
文献类型：
--
作者：
Henderson, Kiersten A.;Gottschling, Daniel E.
芽殖酵母（Saccharomyces cerevisiae）的单个细胞具有有限的寿命，并经历一种称为复制老化的衰老形式。复制寿命被定义为酵母母细胞在停止分裂之前产生的子细胞的数量。复制老化是不对称的：母细胞老化，但她的子细胞的年龄被“重置”为零。因此，已经提出一种或多种衰老因子在母酵母细胞和子酵母细胞之间不对称地积累，并且一旦达到关键阈值就导致母特异性复制性衰老。在这里，我们评估潜在的候选人衰老因子和年龄相关的表型，并讨论潜在的机制不对称的复制老化芽殖酵母。
Individual cells of the budding yeast, Saccharomyces cerevisiae, have a limited life span and undergo a form of senescence termed replicative aging. Replicative life span is defined as the number of daughter cells produced by a yeast mother cell before she ceases dividing. Replicative aging is asymmetric: a mother cell ages but the age of her daughter cells is 'reset' to zero. Thus, one or more senescence factors have been proposed to accumulate asymmetrically between mother and daughter yeast cells and lead to mother-specific replicative senescence once a crucial threshold has been reached. Here we evaluate potential candidates for senescence factors and age-associated phenotypes and discuss potential mechanisms underlying the asymmetry of replicative aging in budding yeast.