MR renography with low-dose gadopentetate dimeglumine: Feasibility
MR renography with low-dose gadopentetate dimeglumine: Feasibility
复制标题
DOI：
10.1148/radiol.2212010142
复制
发表时间：
2001-11-01
期刊：
影响因子：
19.7
通讯作者：
Weinreb, JC
中科院分区：
文献类型：
--
作者：
Lee, VS;Rusinek, H;Weinreb, JC
目的：开发一种低剂量磁共振（MR）血管造影方法，在有或没有血管紧张素转换酶（ACE）抑制剂的情况下，与钆增强磁共振血管造影相结合，用于疑似肾血管疾病的患者。材料与方法：32例患者静脉注射加多戊二胺2ml，静脉注射ACE抑制剂后，进行MR肾造影（turbo快速低角度拍摄序列：重复时间5 msec，回声时间2.3 msec，翻转角度15度，每2秒获取1张冠状面图像，持续4分钟）。同时进行对比材料增强MR血管造影。根据肾造影结果，分析肾皮质和肾髓质增强曲线和归一化增强比率。结果：皮层和髓质在20秒内出现早期短暂性增强（血管期）。在1-2分钟内，观察到血清肌酐水平低于2 mg/dL （177 μ mol/L）的患者比血清肌酐水平高于2 mg/dL的患者有第二次逐渐增加的髓质强化，这反映了过滤造影剂的通过
PURPOSE: To develop a low-dose magnetic resonance (MR) renographic method performed with and without an angiotensin converting enzyme (ACE) inhibitor and in conjunction with gadolinium-enhanced MR angiography in patients with suspected renovascular disease.MATERIALS AND METHODS: Thirty-two patients underwent MR renography (turbo fast low-angle shot sequence: repetition time, 5 msec; echo time, 2.3 msec; flip angle, 15 degrees; one coronal image acquired every 2 seconds for 4 minutes) following intravenous injection of 2 mL of gadopentetate dimeglumine, which was repeated following intravenous injection of an ACE inhibitor. Contrast material-enhanced MR angiography was also performed. On the basis of renographic findings, renal cortex and renal medulla enhancement curves and normalized enhancement ratios were analyzed.RESULTS: The cortex and medulla showed an early transient period of enhancement within 20 seconds (vascular phase). During 1-2 minutes, a second, gradual increase in medullary enhancement, reflecting transit of filtered contrast material, was observed that was significantly greater in patients with a serum creatinine level less than 2 mg/dL (177 mu mol/L) than in those with a level of 2 mg/dL or greater (P