Cortisol administration acutely reduces threat-selective spatial attention in healthy young men
Cortisol administration acutely reduces threat-selective spatial attention in healthy young men
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DOI：
10.1016/j.physbeh.2009.11.006
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发表时间：
2010-03-03
影响因子：
2.9
通讯作者：
van Honk, Jack
中科院分区：
文献类型：
--
作者：
Putman, Peter;Hermans, Erno J.;van Honk, Jack
越来越多的证据表明，单次服用糖皮质激素可以显着减少人类的恐惧。我们之前报道过，皮质醇的施用急剧减少了对恐惧面孔的非空间选择性注意，同样减少了空间工作记忆任务中对恐惧面孔的优先处理。在这里，我们报告了 40 毫克皮质醇（以双盲、安慰剂对照交叉设计给药）对测量威胁选择性注意力的不同实验任务的急性影响。二十名健康的年轻男性必须定位一个出现在外围位置的目标，该目标要么被前面的动态快乐或恐惧的面孔注视，要么不被注视。这种可靠的方法已被反复使用来证明恐惧驱动的选择性注意。目前的结果表明，在服用安慰剂后，与往常一样，恐惧的凝视暗示比快乐的面孔引起更强的注意力定向。皮质醇消除了这种典型的焦虑反应模式，但仅限于低焦虑参与者。这些数据提供的证据表明，皮质醇也强烈影响空间威胁选择性注意力。讨论了可能的神经内分泌机制。 (C) 2009 Elsevier Inc. 保留所有权利。
There is mounting evidence that single administrations of glucocorticoids may acutely reduce human fear. We previously reported that administration of cortisol acutely reduced non-spatial selective attention to fearful faces and likewise reduced preferential processing of fearful faces in a spatial working memory task. Here we report the acute effects of 40 mg cortisol (administered in a double-blind, placebo-controlled crossover design) on a different experimental task for measuring threat-selective attention. Twenty healthy young males had to localize a target which was presented in a peripheral location that was either gazed at or not by a preceding dynamic happy or fearful face. This reliable method has been used repeatedly to demonstrate fear-driven selective attention. Present results showed that after placebo, as usual, the fearful gaze cues caused stronger orienting of attention than happy faces. Cortisol abolished this typical anxious response pattern, but only in low anxious participants. These data provide evidence that cortisol acutely influences also spatial threat-selective attention. Possible neuroendocrine mechanisms are discussed. (C) 2009 Elsevier Inc. All rights reserved.