An oscillatory hierarchy controlling neuronal excitability and stimulus processing in the auditory cortex
An oscillatory hierarchy controlling neuronal excitability and stimulus processing in the auditory cortex
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DOI：
10.1152/jn.00263.2005
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发表时间：
2005-09-01
影响因子：
2.5
通讯作者：
Schroeder, CE
中科院分区：
文献类型：
--
作者：
Lakatos, P;Shah, AS;Schroeder, CE
脑电图振荡被认为反映了神经元兴奋性的周期性变化，特定的频带反映了大脑运作的不同空间尺度。然而，尽管经过数十年的临床和科学研究，脑电图组织并没有统一的理论，持续活动在感觉加工中的作用仍然存在争议。本研究分析了清醒猕猴初级听觉皮层突触活动[电流源密度CSD]和多单位活动（MUA）的层流特征，包括自发的和刺激驱动的。结果表明：脑电具有层次结构；delta （1-4 Hz）相位调制theta （4-10 Hz）振幅，theta相位调制gamma （30-50 Hz）振幅。这种振荡层次控制着基线兴奋性，从而控制着神经元集合中与刺激相关的反应。我们认为，环境振荡活动的分层组织允许听觉皮层结构其时间活动模式，以优化节奏输入的处理。
EEG oscillations are hypothesized to reflect cyclical variations in the neuronal excitability, with particular frequency bands reflecting differing spatial scales of brain operation. However, despite decades of clinical and scientific investigation, there is no unifying theory of EEG organization, and the role of ongoing activity in sensory processing remains controversial. This study analyzed laminar profiles of synaptic activity [ current source density CSD] and multiunit activity (MUA), both spontaneous and stimulus-driven, in primary auditory cortex of awake macaque monkeys. Our results reveal that the EEG is hierarchically organized; delta (1-4 Hz) phase modulates theta (4-10 Hz) amplitude, and theta phase modulates gamma (30-50 Hz) amplitude. This oscillatory hierarchy controls baseline excitability and thus stimulus-related responses in a neuronal ensemble. We propose that the hierarchical organization of ambient oscillatory activity allows auditory cortex to structure its temporal activity pattern so as to optimize the processing of rhythmic inputs.