From innovative applications of the effectiveness-implementation hybrid trial design to the dissemination, implementation, effectiveness, sustainment, economics, and level-of-scaling hybrid trial design.
From innovative applications of the effectiveness-implementation hybrid trial design to the dissemination, implementation, effectiveness, sustainment, economics, and level-of-scaling hybrid trial design.
复制标题
DOI：
10.3389/frhs.2022.1007750
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Garner, Bryan R
中科院分区：
文献类型：
--
作者：
Garner, Bryan R
为了解决研究与实践之间长期存在的差距，需要提高整个转化研究领域的研究速度和效率。 2012年，有效性-实施混合试验设计（HTD）被编纂为具有提高翻译速度和效率潜力的设计，特别是作为T2（临床研究）转化研究的一部分。在此基础上，以及近期其他旨在刺激更多地使用这种新型 HTD 的努力的基础上，本文重点介绍了每种有效性实施 HTD 类型的创新应用。 1 型有效性实施 HTD 的完整应用测试了临床干预措施在降低 HIV 病毒载量和保留 HIV 感染者护理方面的有效性，并进行了纵向混合方法检查，以测试三个关键背景指标随时间的显着变化，以及临床干预的经济评估。 2 型有效性实施 HTD 的完整应用采用双随机设计，同时测试解决 HIV 感染者物质使用障碍的临床干预措施的有效性以及称为实施和维持促进 (ISF) 策略的混合策略的有效性。这种 2 型混合试验也具有创新性，因为它同时关注维持和经济成果。创新型 3 类应用程序（2008 年资助并于 2012 年完成）测试了使用按绩效付费来改善实施成果和客户成果的有效性和成本效益。本文还编纂了称为传播、实施、有效性、维持、经济和扩展水平 (DIeSEL) HTD 的 HTD。
To address the enduring gap between research and practice, there is a need to improve the speed and efficiency of research across the translational research spectrum. In 2012, the effectiveness-implementation hybrid trial design (HTD) was codified as a design with the potential to improve the speed and efficiency of translation, especially as part of T2 (clinical research) translational research. Building on this and other recent efforts to stimulate greater use of this novel HTD, the current article highlights an innovative application of each effectiveness-implementation HTD type. The completed application of the Type 1 effectiveness-implementation HTD tested the effectiveness of a clinical intervention for reducing HIV viral load and retaining people with HIV in care, as well as conducted a longitudinal mixed-methods examination to test for significant changes over time in three key measures of context, and economic evaluation of the clinical intervention. The completed application of the Type 2 effectiveness-implementation HTD used a dual-randomized design to simultaneously test the effectiveness of a clinical intervention for addressing substance use disorder among people with HIV and effectiveness of a blended strategy called the Implementation and Sustainment Facilitation (ISF) Strategy. This Type 2 hybrid trial was also innovative due to its focus on both sustainment and economic outcomes. The innovative Type 3 application (funded in 2008 and completed in 2012) tested the effectiveness and cost-effectiveness of using pay-for-performance to improve both implementation outcomes and client outcomes. This article also codifies a HTD called the Dissemination, Implementation, effectiveness, Sustainment, Economics, and Level-of-scaling (DIeSEL) HTD.
影响因子：
--
作者：
Hinde, Jesse M.;Garner, Bryan R.;Watson, Colleen J.;Ramanan, Rasika;Ball, Elizabeth L.;Tueller, Stephen J.
通讯作者：
Tueller, Stephen J.