ACQUISITION OF DONOR STRAINS OF CYTOMEGALOVIRUS BY RENAL-TRANSPLANT RECIPIENTS
ACQUISITION OF DONOR STRAINS OF CYTOMEGALOVIRUS BY RENAL-TRANSPLANT RECIPIENTS
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DOI：
10.1056/nejm198605293142205
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发表时间：
1986-05-29
影响因子：
158.5
通讯作者：
CHOU, SW
中科院分区：
文献类型：
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作者：
CHOU, SW
为了确定肾移植受者移植后巨细胞病毒（CMV）感染的来源，从接受同一尸体肾脏的成对患者中收集病毒分离株。在36对受者中，4对受者同时出现CMV病毒尿或病毒血症，11对受者中有1对出现CMV病毒尿或病毒血症。病毒DNA的限制性内切酶分析显示，从这19例患者的病毒分离株中有15种不同的CMV株。在所有四对中，两个成员都脱落了CMV，两个受体脱落了相同的毒株，这表明病毒是供体来源的。在其中三对中，一名成员在移植前CMV血清阳性。一个血清阳性受体同时脱落两株CMV移植后，一株是供体来源。两名在接受血清阳性供体移植物前有CMV病毒尿症的患者在移植后两个月脱落了不同的CMV毒株。这些研究结果表明，尸体移植物可以传输一个可识别的CMV株受体，血清阳性受体可以重新感染一个新的CMV株从供体移植后。
To determine the source of post-transplantation cytomegalovirus (CMV) infection in renal-transplant recipients, viral isolates were collected from pairs of patients who received kidneys from the same cadaver. Among 36 pairs of recipients, CMV viruria or viremia occurred in both members of 4 pairs and in one member of11 pairs. Restriction-enzyme analysis of viral DNA revealed 15 distinct strains of CMV among viral isolates from these 19 patients. In all four pairs in which both members shed CMV, both recipients shed the same strain, suggesting that the virus was of donor origin. In three of these pairs, one member had been seropositive for CMV before transplantation. One seropositive recipient was simultaneously shedding two strains of CMV after transplantation; one strain was of donor origin. Two patients who had CMV viruria before receiving grafts from a seropositive donor shed a different CMV strain two months after grafting. These findings indicate that cadaveric grafts can transmit an identifiable strain of CMV to recipients, and that seropositive recipients can be reinfected by a new CMV strain from the donor after transplantation.