Prognostic Nutritional Index Predicts Postoperative Outcome in Colorectal Cancer
Prognostic Nutritional Index Predicts Postoperative Outcome in Colorectal Cancer
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DOI：
10.1007/s00268-013-2156-9
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发表时间：
2013-11-01
影响因子：
2.6
通讯作者：
Kusunoki, Masato
中科院分区：
文献类型：
--
作者：
Mohri, Yasuhiko;Inoue, Yasuhiro;Kusunoki, Masato
基于血清白蛋白浓度和外周血淋巴细胞计数计算的预后营养指数（PNI）是预测癌症手术患者术后短期和长期预后的有用工具。然而，很少有研究调查PNI在结直肠癌手术中的应用。我们检验了PNI预测结直肠癌患者短期和长期预后的能力。方法对365例结直肠癌患者进行回顾性研究。根据入院数据计算预后营养状况：10 ×血清白蛋白(g/dl) + 0.005 ×总淋巴细胞计数（每mm(3)）。测量的主要结果是PNI对总生存和术后并发症的影响。结果Kaplan-Meier分析和log rank检验显示，低PNI与低生存率显著相关（P < 0.0001）。在多变量生存分析中，术前低PNI是生存不良的独立预后因素：优势比：2.25,95%可信区间1.42-3.59)。此外，低PNI与术后并发症，尤其是严重并发症的发生率显著相关。结论术前PNI是预测结直肠癌患者术后并发症和生存率的有效指标。
Background The prognostic nutritional index (PNI), which is calculated based on the serum albumin concentration and peripheral blood lymphocyte count, is a useful tool for predicting short-term and long-term postoperative outcome in patients undergoing cancer surgery. However, few studies have investigated PNI in colorectal cancer surgery. We examined the ability of PNI to predict shortand long-term outcomes in patients with colorectal cancer.Methods This retrospective study included 365 patients who underwent resection for colorectal cancer. The prognostic nutritional status was calculated on the basis of admission data as follows: 10 x serum albumin (g/dl) + 0.005 x total lymphocyte count (per mm(3)). The primary outcomes measured were the impact of PNI on overall survival and postoperative complications.Results Kaplan-Meier analysis and the log rank test revealed that low PNI was significantly associated with poor survival (P < 0.0001). In multivariate analysis for survival, preoperative low PNI was an independent prognostic factor for poor survival: odds ratio: 2.25, 95 % confidence interval 1.42-3.59). Moreover, low PNI significantly correlated with the incidence of postoperative complications, especially serious ones.Conclusions Preoperative PNI is a useful predictor of postoperative complications and survival in patients with colorectal cancer.