ATPase activity in discharging cortical lesions induced by freezing.
ATPase activity in discharging cortical lesions induced by freezing.
复制标题
解除冷冻诱导的皮质损伤中的 ATP 酶活性。
DOI：
10.1001/archneur.1967.00470210097010
复制
发表时间：
1967
影响因子：
--
通讯作者：
A. McCrimmon
中科院分区：
文献类型：
--
作者：
E. Levin;A. McCrimmon
在实验动物中产生异常放电的皮层病灶提供了一种与人类局灶性癫痫有某些相似之处的模型。局部皮层冷冻是几种有效的致痫性病变的方法之一。Nims等人使用氯乙烷喷雾来产生冷冻皮层损伤，1最近Morrell等人详细描述了使用相同方法的结果。[2]尽管大鼠对皮层冷冻有相对的抵抗力，[3] Morrell的技术已被证明能有效地诱导该动物的异常放电损伤，下面将描述大鼠的经验。这种病变对于研究与脑电图异常相关的化学改变是有用的。选择需要Na +和K +以及Mg ++完全激活的ATP酶（Na-K-ATP酶）进行研究，因为该酶与Na +和K的运输有关
THE PRODUCTION of abnormally discharging cortical foci in experimental animals provides a model having some resemblance to human focal epilepsy. Local cortical freezing is one of several procedures which have been effective in producing epileptogenic lesions. Nims et al employed an ethyl chloride spray to produce a freezing cortical lesion, 1 and more recently Morrell et al have described in detail results with the same method. 2 Although the rat has been said to be relatively resistant to cortical freezing, 3 Morrell's technique has proved effective in inducing abnormally discharging lesions in this animal, and experience with the rat will be described. Such lesions should be useful for investigating chemical alterations associated with the resulting electroencephalographic abnormality. The ATPase requiring Na + and K + as well as Mg ++ for full activation (Na-K-ATPase) was selected for study because of the suggested association of this enzyme with transport of Na + and K