Risk factors associated with seropositivity for Toxoplasma gondii in population-based studies among immunocompromised patients (pregnant women, HIV patients and children) in West African countries, Cameroon and Gabon: a meta-analysis
Risk factors associated with seropositivity for Toxoplasma gondii in population-based studies among immunocompromised patients (pregnant women, HIV patients and children) in West African countries, Cameroon and Gabon: a meta-analysis
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DOI：
10.1016/j.actatropica.2020.105544
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发表时间：
2020-09-01
期刊：
影响因子：
2.7
通讯作者：
Ademola, Isaiah Oluwafemi
中科院分区：
文献类型：
--
作者：
Odeniran, Paul Olalekan;Omolabi, Kehinde Foluke;Ademola, Isaiah Oluwafemi
免疫功能低下者感染弓形虫可能危及生命。西非流行国家缺乏适当控制和管理策略所需的信息，因此进行了系统综述和荟萃分析。本研究旨在确定西非、喀麦隆和加蓬的孕妇、艾滋病患者和儿童中抗弓形虫的血清阳性率。通过PubMed、Web of Science、Ovid MEDLINE、AJOL和Google Scholar数据库确定了1984年至2019年间发表的有关该疾病的流行病学研究。对符合系统综述和荟萃分析首选报告项目（PRISMA）清单中弓形虫感染纳入标准的研究进行了分析。共有58项符合条件的研究被选入荟萃分析。这些研究涉及18674名宿主，孕妇、艾滋病患者和儿童的抗弓形虫抗体总体合并血清阳性率分别为45.4%、39.0%和29.5%。孕妇的合并血清阳性率在加蓬最高，在马里最低，而艾滋病患者和儿童的抗弓形虫抗体血清阳性率最高水平均在加纳观察到。与抗弓形虫血清阳性相关的主要危险因素是孕次、与猫接触、食用生蔬菜和/或水果、年龄和CD4细胞计数。需要更多研究来确定血清转换率。提高免疫功能低下患者对弓形虫及其危险因素的认识将是降低该疾病患病率的有效方法。需要涉及跨学科、综合研究和能力建设的“同一健康”干预措施来解决西非的弓形虫病问题。
Toxoplasmosis in immunocompromised individuals can be life threatening. The information needed for proper control and management strategies in endemic West African countries is lacking, hence a systematic review and meta-analysis were performed. This study aimed to determine the seroprevalence of anti-Toxoplasma gondii among pregnant women, HIV/AIDS and children in West Africa, Cameroon and Gabon. The epidemiology of the disease published between 1984 and 2019 using PubMed, Web of Science, Ovid MEDLINE, AJOL and Google Scholar databases were identified. Studies that met the inclusion criteria of Toxoplasma gondii infections under the preferred reporting items for systematic reviews and meta-analyses (PRISMA) checklist were analysed. A total of 58 eligible studies were selected for meta-analysis. These studies considered 18,674 hosts and an overall pooled seroprevalence of anti-T. gondii antibodies were 45.4, 39.0 and 29.5% for pregnant women, HIV/AIDS patients and children, respectively. Pooled seroprevalence was highest in Gabon and lowest in Mali for pregnant women while highest levels of seropositivity for anti-T. gondii antibodies for HIV/AIDS individuals and children were both observed in Ghana. The major risk factors associated with anti-T. gondii seropositivity were gravida status, contact with cats, consumption of raw vegetables and /fruits, age and CD4 counts. More studies are needed to determine seroconversion rate. Improved sensitization among immunocompromised patients on T. gondii and its risk factors will be an efficient method to reducing the prevalence of the disease. One Health interventions involving transdisciplinary, integrative research and capacity building are necessary to address the problem of toxoplasmosis in West Africa.