VITAMIN DEFICIENCIES AND NEURAL TUBE DEFECTS
VITAMIN DEFICIENCIES AND NEURAL TUBE DEFECTS
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DOI：
10.1136/adc.51.12.944
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发表时间：
1976-01-01
影响因子：
5.2
通讯作者：
SCHORAH, CJ
中科院分区：
文献类型：
--
作者：
SMITHELLS, RW;SHEPPARD, S;SCHORAH, CJ
本文对900余例妊娠早期孕妇进行了血清叶酸、红细胞叶酸、白色细胞维生素C、核黄素饱和指数和血清维生素A的测定。对于每一个这些都有一个社会阶层I + II显示出最高的水平，显着不同于其他类，除了血清叶酸。在6名分娩神经管缺陷婴儿的母亲中，妊娠早期血清叶酸、红细胞叶酸、白色血细胞维生素C和核黄素值低于对照组。红细胞叶酸（P <0-001）和白色血细胞维生素C（P <0-05）的差异尽管很小。这些发现与营养缺乏是导致人类神经管先天性缺陷的重要原因的假设是一致的。
Serum folate, red cell folate, white blood cell vitamin C, riboflavin saturation index, and serum vitamin A were determined during the first trimester of pregnancy in over 900 cases. For each of these there was a social classes I + II showed the highest levels which differed significantly from other classes, except for serum folate. In 6 mothers who gave birth to infants with neural tube defects, first trimester serum folate, red cell folate, white blood cell vitamin C, and riboflavin values were lower than in controls. In spite of small numbers the differences were significant for red cell folate (P less than 0-001) and white blood cell vitamin C (P less than 0-05). These findings are compatible with the hypothesis that nutritional deficiencies are significant in the causation of congenital defects of the neural tube in man.