Pallidal low-frequency activity in dystonia after cessation of long-term deep brain stimulation
Pallidal low-frequency activity in dystonia after cessation of long-term deep brain stimulation
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DOI：
10.1002/mds.27838
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发表时间：
2019-11-01
影响因子：
8.6
通讯作者：
Kuehn, Andrea A.
中科院分区：
文献类型：
--
作者：
Scheller, Ute;Lofredi, Roxanne;Kuehn, Andrea A.
目的探讨慢性深部脑刺激数月后肌张力障碍患者苍白质低频活动与运动体征严重程度的关系。方法采用Burke-Fahn-Marsden肌张力障碍评定量表对9例肌张力障碍患者进行5 ~ 7小时off刺激期间5个时间点（t1 ~ t5）的局部场电位记录，并进行临床评估。采用线性混合效应模型研究低频（3-12 Hz）和β范围（13-30 Hz）运动信号与局部场电位活动的潜在关联。结果伯克-法恩-马斯登肌张力障碍评定量表得分与低频活动（3-12 Hz, b = 4.4，标准误差= 1.5，自由度= 43,P = 0.006, 95%置信区间为1.3-7.5）显著相关，但在不同时间点的参与者中没有发现β活动（13-30 Hz）。结论低频活动与肌张力障碍运动体征严重程度相关，甚至在慢性深部脑刺激后数月也存在。我们的研究结果证实了低频活动在肌张力障碍中的病理生理作用，并强调了作为适应性神经调节生物标志物的潜在效用。(c) 2019年国际帕金森和运动障碍学会
Objective This study investigates the association between pallidal low-frequency activity and motor sign severity in dystonia after chronic deep brain stimulation for several months. Methods Local field potentials were recorded in 9 dystonia patients at 5 timepoints (T1-T5) during an OFF-stimulation period of 5 to 7 hours in parallel with clinical assessment using Burke-Fahn-Marsden Dystonia Rating Scale. A linear mixed effects model was used to investigate the potential association of motor signs with local field potential activity in the low frequency (3-12 Hz) and beta range (13-30 Hz). Results A significant association of Burke-Fahn-Marsden Dystonia Rating Scale scores with low-frequency activity (3-12 Hz; b = 4.4; standard error = 1.5, degrees of freedom = 43, P = 0.006, 95% confidence interval, 1.3-7.5), but not beta activity (13-30 Hz) was revealed within participants across timepoints. Conclusion Low-frequency activity is associated with dystonic motor sign severity, even months after chronic deep brain stimulation. Our findings corroborate the pathophysiological role of low-frequency activity in dystonia and highlight the potential utility as a biomarker for adaptive neuromodulation. (c) 2019 International Parkinson and Movement Disorder Society