Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy
Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy
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DOI：
10.1038/sj.bmt.1701788
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发表时间：
1999-06-01
影响因子：
4.8
通讯作者：
Milligan, DW
中科院分区：
文献类型：
--
作者：
Chakrabarti, S;Collingham, KE;Milligan, DW
腺病毒感染引起的暴发性肝功能衰竭是干细胞移植后罕见的并发症。我们报告了一个无关的骨髓移植受者移植后30周的并发症。在入院后36小时内开始静脉注射利巴韦林治疗，但他死于异常的暴发性肝衰竭。从粪便监测样本和尸检肝脏样本中分离出2型腺病毒。在入院时的血液和痰标本中通过PCR检测到腺病毒DNA，并在死后的肝组织中通过电子显微镜鉴定出腺病毒DNA，讨论了利巴韦林治疗失败的意义。
Fulminant hepatic failure due to adenovirus infection is a rare complication following stem cell transplantation. We report this complication in an unrelated bone marrow transplant recipient 30 weeks post-transplant. Treatment with intravenous ribavirin was started within 36 h of admission, but he succumbed to unusually fulminant hepatic failure. Adenovirus type 2 was isolated from stool surveillance samples and from post-mortem liver samples. Adenovirus DNA was detected by PCR in blood and sputum samples at admission and was identified in post-mortem liver tissue by electron microscopy, Implications of the failure of ribavirin therapy are discussed.