PSYCHOSOCIAL FACTORS PREDICTIVE OF SURVIVAL AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR LEUKEMIA
PSYCHOSOCIAL FACTORS PREDICTIVE OF SURVIVAL AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR LEUKEMIA
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DOI：
10.1097/00006842-199409000-00008
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发表时间：
1994-09-01
影响因子：
3.3
通讯作者：
HENSLEEDOWNEY, PJ
中科院分区：
文献类型：
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作者：
ANDRYKOWSKI, MA;BRADY, MJ;HENSLEEDOWNEY, PJ
先前的研究表明，心理社会变量与骨髓移植（BMT）后生存之间的联系受到以下因素的限制：a）心理社会变量的回顾性评估； b) 未能同时检查与 BMT 后生存可能相关的一组全面的疾病、治疗和人口变量。本研究前瞻性评估了与 BMT 和/或恶性疾病后生存相关的心理社会变量（抑郁情绪、功能生活质量和对癌症的心理调整）。研究参与者 (N = 42) 因急性或慢性白血病接受同种异体 BMT，使用 Cox 比例风险回归分析表明，骨髓移植匹配的质量是与 BMT 后生存显着相关的唯一疾病、治疗或人口统计学变量 (p = .05)。将心理社会变量添加到多变量 Cox 回归模型（包括移植物匹配质量）表明，以“焦虑全神贯注”为特征的对癌症的态度（p = .008）以及较差的功能生活质量（p = .052）均与较差的 BMT 生存率独立相关。需要进一步研究来确定社会心理变量对 PMT 后生存产生影响的机制。
Previous research suggesting a link between psychosocial variables and survival after bone marrow transplant (BMT) has been limited by: a) retrospective assessment of psychosocial variables; and b) failure to concurrently examine a comprehensive set of disease, treatment, and demographic variables potentially related to post-BMT survival. The present study prospectively assessed psychosocial variables (depressed mood, functional quality of life, and mental adjustment to cancer) that have been linked to survival after BMT and/or malignant disease. Study participants (N = 42) received allogeneic BMT for either acute or chronic leukemia, Analyses using Cox proportional hazards regression indicated that quality of bone marrow graft match was the only disease, treatment, or demographic variable significantly associated with post-BMT survival (p = .05). Addition of psychosocial variables to a multivariate Cox regression model including quality of graft match suggested that an attitude toward cancer characterized by ''anxious preoccupation'' (p = .008), as well as poorer functional quality of life (p = .052), were each independently associated with poorer post-BMT survival. Further research is necessary to identify the mechanisms by which psychosocial variables could contribute to post-PMT survival.