Numerical model for calculation of apparent diffusion coefficients (ADC) in permeable cylinders - Comparison with measured ADC in spinal cord white matter
Numerical model for calculation of apparent diffusion coefficients (ADC) in permeable cylinders - Comparison with measured ADC in spinal cord white matter
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DOI：
10.1002/mrm.1910370315
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发表时间：
1997-03-01
影响因子：
3.3
通讯作者：
Hackney, DB
中科院分区：
文献类型：
--
作者：
Ford, JC;Hackney, DB
我们已经实现了一个数值方法计算的表观扩散系数（ADC）在脊髓损伤，其中考虑到轴突直径的分布和渗透性发现在脊髓白色物质，以及相对轴突体积。我们提出了一个程序来确定状态的轴突完整性从测量ADC值。这些方法已被应用到一个很好的特点大鼠脊髓损伤模型，提供了一个预测的轴突通透性的增加，这被认为是密切相关的功能缺陷。ADC值进行了比较，从文献中的分析公式计算，并探讨了ADC行为的可能因素。计算结果表明，轴索肿胀和细胞膜通透性是导致创伤性脊髓损伤ADC的重要因素。
We have implemented a numerical method for calculation of the apparent diffusion coefficient (ADC) in spinal cord injury, which takes into account the distribution of axon diameters and permeability found in spinal cord white matter, as well as relative axonal volume. We propose a procedure for determining the status of axonal integrity from measured ADC values. These methods have been applied to a well characterized rat spinal cord injury model, affording a prediction of the increase in axonal permeability which is presumed to be closely related to functional deficit. ADC values are compared to those calculated from analytical formulas in the literature, and possible factors underlying the ADC behavior are explored. Calculated results indicate both axonal swelling and cell membrane permeability to be important factors contributing to ADC in traumatic spinal cord injury.