Studying the human brain anatomical network via diffusion-weighted MRI and Graph Theory
Studying the human brain anatomical network via diffusion-weighted MRI and Graph Theory
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DOI：
10.1016/j.neuroimage.2007.10.060
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发表时间：
2008-04-15
期刊：
影响因子：
5.7
通讯作者：
Melie-Garcia, Lester
中科院分区：
文献类型：
--
作者：
Iturria-Medina, Yasser;Sotero, Roberto C.;Melie-Garcia, Lester
我们的目标是研究人脑解剖网络。为此，利用扩散加权磁共振成像(DW-MRI)技术估计了90个大脑皮质和皮质下灰质区域之间的解剖连接概率(ACP)。任何两个区域之间的ACP给出了这些区域至少由一根神经纤维连接的可能性。然后，将大脑建模为一个由ACP矩阵给出的具有连续弧权的无向加权图。基于该方法，研究了复杂网络的小世界属性、效率、度分布、脆弱性、介数中心性和模体组成等性质。分析对象为20名右利手健康受试者(平均年龄31.10岁，S.D.：7.43岁)。结果表明，所有网络都具有小世界和大尺度的特点。此外，与相应的随机网络相比，人脑解剖网络表现出更大的局部效率和更小的全局效率。在脆弱性和中间性中心性分析中，确定了最不可或缺和最关键的解剖学区域：壳核、楔前、胰岛、顶上和额上。有趣的是，一些区域具有负面的脆弱性(例如，颞上极、苍白球、边缘上极和高位)，这表明即使以失去整体解剖效率为代价，这些结构由于其重要的功能而在进化过程中得以维持。最后计算了尺寸为3和4的对称特征构建块(Motif)，得到尺寸为4的Motif是尺寸为3的Motif的扩展版本。这些结果与猫和猕猴大脑皮层先前的解剖学研究相一致。(C)2008年，爱思唯尔公司出版。
Our goal is to study the human brain anatomical network. For this, the anatomical connection probabilities (ACP) between 90 cortical and subcortical brain gray matter areas are estimated from diffusion-weighted Magnetic Resonance Imaging (DW-MRI) techniques. The ACP between any two areas gives the probability that those areas are connected at least by a single nervous fiber. Then, the brain is modeled as a non-directed weighted graph with continuous arc weights given by the ACP matrix. Based on this approach, complex networks properties such as small-world attributes, efficiency, degree distribution, vulnerability, betweenness centrality and motifs composition are studied. The analysis was carried out for 20 right-handed healthy subjects (mean age: 31.10, S. D.: 7.43). According to the results, all networks have small-world and broad-scale characteristics. Additionally, human brain anatomical networks present bigger local efficiency and smaller global efficiency than the corresponding random networks. In a vulnerability and betweenness centrality analysis, the most indispensable and critical anatomical areas were identified: putamens, precuneus, insulas, superior parietals and superior frontals. Interestingly, some areas have a negative vulnerability (e. g. superior temporal poles, pallidums, supramarginals and hechls), which suggest that even at the cost of losing in global anatomical efficiency, these structures were maintained through the evolutionary processes due to their important functions. Finally, symmetrical characteristic building blocks (motifs) of size 3 and 4 were calculated, obtaining that motifs of size 4 are the expanded version of motif of size 3. These results are in agreement with previous anatomical studies in the cat and macaque cerebral cortex. (C) 2008 Published by Elsevier Inc.