Neonate characteristics after maternal use of antidepressants in late pregnancy
Neonate characteristics after maternal use of antidepressants in late pregnancy
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DOI：
10.1001/archpedi.158.4.312
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发表时间：
2004-04-01
影响因子：
--
通讯作者：
Källén, B
中科院分区：
文献类型：
--
作者：
Källén, B
背景：妊娠晚期接触抗抑郁药物与不良分娩结局的风险增加相关，包括早产、呼吸窘迫和低血糖。目的：根据产前护理文件中前瞻性记录的信息，调查 997 名婴儿（987 名母亲）在母亲使用抗抑郁药物后的新生儿结局。结果：早产风险增加（比值比 [OR]，1.96）和低出生体重（OR，1.98）得到验证，但暴露于三环类抗抑郁药后特定孕周出生体重显着增加。发现阿普加评分低（OR，2.33）、呼吸窘迫（OR，2.21）、新生儿惊厥（OR，1.90）和低血糖（OR，1.62）的风险增加，后者尤其是在接触三环类药物后，但对新生儿黄疸的频率没有显着影响（OR，1.13）。大多数影响似乎不是选择性5-羟色胺再摄取抑制剂药物特异性的，并且暴露于盐酸帕罗西汀后的结果并不比暴露于其他选择性5-羟色胺再摄取抑制剂后更差。 结论：观察到母亲在妊娠晚期使用抗抑郁药物后对新生儿的影响。选择性血清素再摄取抑制剂可能是怀孕期间的首选药物。
Background: Exposure to antidepressants during the third trimester of pregnancy has been associated with an increased risk for adverse birth outcomes, including preterm birth, respiratory distress, and hypoglycemia.Objective: To investigate neonatal outcomes in 997 infants (987 mothers) after maternal use of antidepressants based on prospectively recorded information in antenatal care documents.Results: An increased risk for preterm birth (odds ratio [OR], 1.96) and low birth weight (OR, 1.98) was verified, but the gestational week-specific birth weight was increased notably after exposure to tricyclic antidepressants. An increased risk for a low Apgar score (OR, 2.33), respiratory distress (OR, 2.21), neonatal convulsions (OR, 1.90), and hypoglycemia (OR, 1.62) was found, the latter especially after exposure to tricyclic drugs, but no significant effect on the frequency of neonatal jaundice was seen (OR, 1.13). Most effects seemed not to be selective serotonin reuptake inhibitor drug specific, and outcomes after exposure to paroxetine hydrochloride were not worse than after exposure to other selective serotonin reuptake inhibitors.Conclusions: Neonatal effects after maternal use of antidepressant drugs during late pregnancy were seen. Selective serotonin reuptake inhibitors may be the drugs of choice during pregnancy.