The influence of antibiotics on wastewater treatment processes and the development of antibiotic-resistant bacteria
The influence of antibiotics on wastewater treatment processes and the development of antibiotic-resistant bacteria
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DOI：
10.2166/wst.2018.153
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发表时间：
2018-05-01
影响因子：
2.7
通讯作者：
Karwowska, E.
中科院分区：
文献类型：
--
作者：
Jendrzejewska, N.;Karwowska, E.
抗生素，即强力霉素，庆大霉素，青霉素，呋喃妥因，利福平，对废水处理的影响进行了评估。100-300 μ g/L的抗生素（63.52-134.41 mg/g.d.w.d）的存在对有机物降解的影响很小，而不影响氮或磷浓度。然而，观察到耐药细菌的数量显著增加，这因不同抗生素而异。大多数细菌对呋喃妥因和青霉素产生了耐药性。处理后，从污泥中分离到一些多重抗性菌株。其中两项研究揭示了碳青霉烯酶的活性，该酶与对β-内酰胺类抗生素的耐药性直接相关。
The influence of antibiotics, namely doxycycline, gentamicin, penicillin, nitrofurantoin, and rifampicin, on wastewater treatment was assessed. The presence of 100-300 mu g/L of antibiotics (63.52-134.41 mg/g.d.w.d) marginally influenced organic matter degradation, without impacting nitrogen or phosphorus concentrations. However, a significant increase in the number of antibiotic-resistant bacteria was observed, which varied with different antibiotics. The largest number of bacteria became resistant to nitrofurantoin and penicillin. After the process, some multi-resistant strains were isolated from the sludge. Two of them revealed the activity of carbapenamase, the enzyme directly related to resistance against beta-lactam antibiotics.