The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization
The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization
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DOI：
10.1126/science.1143708
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发表时间：
2007-09-07
期刊：
影响因子：
56.9
通讯作者：
Kistler, H. Corby
中科院分区：
文献类型：
--
作者：
Cuomo, Christina A.;Gueldener, Ulrich;Kistler, H. Corby
我们测序和注释的丝状真菌禾谷镰刀菌，一个主要的病原体栽培谷物的基因组。检测到的重复序列非常少，重复诱导的点突变过程（重复序列发生广泛突变）可能部分解释了重复序列含量减少和旁系同源（祖先重复）基因数量明显减少的原因。第二株F. graminearum含有10，000多个单核苷酸多态性，这些多态性通常位于端粒附近和其他离散的染色体片段内。许多高度多态性的区域包含植物-真菌相互作用中涉及的基因组，并且异常发散，具有较高的重组率。这些基因组创新区域可能是由于F. graminearum及其植物宿主。
We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.