A model for comprehensive oral biological age score with oral and systemic clinical parameters
A model for comprehensive oral biological age score with oral and systemic clinical parameters
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具有口腔和全身临床参数的综合口腔生物年龄评分模型
DOI：
10.1111/jop.12890
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发表时间：
2020
影响因子：
3.3
通讯作者：
Jiang Wei-Wen
中科院分区：
文献类型：
--
作者：
He Zhi-Chao;Sun Chen;Jiang Wei-Wen
研究背景生物学年龄反映了个体的机能状态。方法对248例常规体检者进行口腔及全身临床检查，采用卡方检验筛选口腔临床候选指标。一般参数采用Pearson相关系数和主成分分析法进行分析，得出一般生物学年龄评分。将口腔生物学年龄评分与一般生物学年龄评分相结合，最终建立口腔生物学年龄评分综合模型（粘膜血疱、粘膜干燥、埋伏牙、缺牙、残冠、牙结石、牙龈充血、牙龈退缩）和10项一般临床指标（甘油三酯、肌酸酐、血尿素氮、葡萄糖、总胆固醇、平均红细胞血红蛋白浓度、平均红细胞血红蛋白、尿酸、体重，口腔生物学年龄评分与一般生物学年龄评分的相关系数分别为（r> 0.25，P < 0.05）。然后通过主成分分析形成综合口腔生物学年龄评分模型：0.046甘油三酯+0.010肌酐+0.141血尿素氮+0.048葡萄糖+0.068总胆固醇+0.014平均红细胞血红蛋白浓度+0.082平均红细胞血红蛋白+0.001尿酸+0.020体重+0.005收缩压+0.037口腔生物学年龄评分-10.908。结论口腔生物学年龄综合评分模型可方便地由全科医生根据口腔和全身临床参数进行口腔生物学年龄的临床评估。
BackgroundBiological age reflects the functional status of an individual. The purpose of the study was to develop a model for estimating oral biological age with oral and systemic parameters.MethodsA total of 248 subjects who had a routine health check were assessed with oral and general clinical examination.Chi‐squaretest was performed to screen oral clinical candidate indicators. General parameters were analyzed byPearson correlation coefficientandprincipal component analysisto develop a general biological age score. A final comprehensive model of oral biological age score was established by combining oral and general biological age score.ResultsA total of eight oral indicators (mucosal blood blister, mucosal dryness, impacted tooth, missing teeth, residual crowns, dental calculus, gingival hyperemia, and gingival recession) and 10 general clinical indicators (triglyceride, creatinine, blood urea nitrogen, glucose, total cholesterol, mean erythrocyte hemoglobin concentration, mean erythrocyte hemoglobin, uric acid, body weight, and systolic blood pressure) were selected for oral and general biological age score, respectively (r> 0.25,P< 0.05). A model of comprehensive oral biological age score was then formed by principal component analysis: 0.046 triglyceride + 0.010 creatinine + 0.141 blood urea nitrogen + 0.048 glucose + 0.068 total cholesterol + 0.014 mean erythrocyte hemoglobin concentration + 0.082 mean erythrocyte hemoglobin + 0.001 uric acid + 0.020 body weight + 0.005 systolic blood pressure + 0.037 oral biological age score −10.908. The score was increased accordingly with CA.ConclusionOral biological age can be easily estimated clinically by the model of comprehensive oral biological age score using oral and systemic clinical parameters by general practitioners.