Multiplicative computation in the vestibulo-ocular reflex (VOR)
Multiplicative computation in the vestibulo-ocular reflex (VOR)
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DOI：
10.1152/jn.00812.2006
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发表时间：
2007-04-01
影响因子：
2.5
通讯作者：
Cai, Yidao
中科院分区：
文献类型：
--
作者：
Zhou, Wu;Xu, Youguo;Cai, Yidao
乘法计算是神经信息处理中至关重要的基本运算，但通过神经通路执行明确定义的感觉运动变换的乘法运算的例子很少。在表现良好的猴子身上，我们发现了前庭和眼睛位置信号在前庭-眼睛反射(VOR)中的倍增。训练猴子在不同的水平位置保持对视觉目标的注视，并接受短暂的单侧声学短声(1ms，稀疏，85类似于110db非霍奇金淋巴瘤)，并将其送入它们的一个外耳道。我们发现，短声诱发的水平眼动反应和短声诱发的外展神经元反应均与水平共轭眼位呈线性依赖关系，说明前庭和水平共轭眼位的相互作用是乘性的。潜伏期分析进一步表明，倍增的位置在直接的VOR通路内。基于这些结果，我们提出了一种新的神经机制，通过注视距离和凝视偏心来实现VOR增益调制。在这个机制中，来自单个迷宫的前庭信号与每只眼睛的位置信号进行乘法相互作用(乘法原理)。然而，这些效应与另一个迷宫相加地相互作用(相加原理)。我们的分析表明，新的机制可以通过直接VOR路径内的注视距离和凝视偏心来实现VOR增益调制。
Multiplicative computation is a basic operation that is crucial for neural information processing, but examples of multiplication by neural pathways that perform well-defined sensorimotor transformations are scarce. Here in behaving monkeys, we identified a multiplication of vestibular and eye position signals in the vestibulo-ocular reflex (VOR). Monkeys were trained to maintain fixation on visual targets at different horizontal locations and received brief unilateral acoustic clicks (1 ms, rarefaction, 85 similar to 110 db NHL) that were delivered into one of their external ear canals. We found that both the click-evoked horizontal eye movement responses and the click-evoked neuronal responses of the abducens neurons exhibited linear dependencies on horizontal conjugate eye position, indicating that the interaction of vestibular and horizontal conjugate eye position was multiplicative. Latency analysis further indicated that the site of the multiplication was within the direct VOR pathways. Based on these results, we propose a novel neural mechanism that implements the VOR gain modulation by fixation distance and gaze eccentricity. In this mechanism, the vestibular signal from a single labyrinth interacts multiplicatively with the position signals of each eye (Principle of Multiplication). These effects, however, interact additively with the other labyrinth (Principle of Addition). Our analysis suggests that the new mechanism can implement the VOR gain modulation by fixation distance and gaze eccentricity within the direct VOR pathways.