The Catalogue of Somatic Mutations in Cancer (COSMIC).
The Catalogue of Somatic Mutations in Cancer (COSMIC).
复制标题
癌症中躯体突变的目录（宇宙）。
DOI：
10.1002/0471142905.hg1011s57
复制
发表时间：
2008-04
影响因子：
--
通讯作者：
Stratton, M R
中科院分区：
文献类型：
--
作者：
Forbes, S A;Bhamra, G;Bamford, S;Dawson, E;Kok, C;Clements, J;Menzies, A;Teague, J W;Futreal, P A;Stratton, M R
COSMIC目前是关于人类癌症体细胞突变信息的最全面的全球资源，将科学文献的精选与英国桑格研究所癌症基因组计划的肿瘤重新测序数据相结合。近4,800个基因和250000个肿瘤已被检查，导致超过50000个突变可供研究。可以通过多种方式访问这些信息，其中最方便的是基于Web的系统，该系统允许进行详细的数据挖掘，并以易于解释的格式显示结果。本单元详细描述了图形系统，详细介绍了一个示例演练，以及通过组合数据、重新指定查询或以不同方式查看结果来彻底调查结果的许多方法。备用协议概述了可供下载的可用预编译数据文件。
COSMIC is currently the most comprehensive global resource for information on somatic mutations in human cancer, combining curation of the scientific literature with tumor resequencing data from the Cancer Genome Project at the Sanger Institute, U.K. Almost 4800 genes and 250000 tumors have been examined, resulting in over 50000 mutations available for investigation. This information can be accessed in a number of ways, the most convenient being the Web-based system which allows detailed data mining, presenting the results in easily interpretable formats. This unit describes the graphical system in detail, elaborating an example walkthrough and the many ways that the resulting information can be thoroughly investigated by combining data, respecializing the query, or viewing the results in different ways. Alternate protocols overview the available precompiled data files available for download.