The microtubule depolymerizing drugs nocodazole and colchicine inhibit the uptake of Listeria monocytogenes by P388D1 macrophages
The microtubule depolymerizing drugs nocodazole and colchicine inhibit the uptake of Listeria monocytogenes by P388D1 macrophages
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DOI：
10.1111/j.1574-6968.1998.tb12895.x
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发表时间：
1998-03-01
影响因子：
2.1
通讯作者：
Kuhn, M
中科院分区：
文献类型：
--
作者：
Kuhn, M
不同哺乳动物细胞如巨噬细胞和上皮细胞对单核细胞增生李斯特菌的摄取依赖于功能性肌动蛋白丝，因此容易受到细胞松弛素的抑制。在这里，我们表明，吞噬摄取L。（1）巨噬细胞对微管解聚药物诺考达唑和秋水仙碱的治疗也高度敏感。这种敏感性是细胞类型特异性的，在骨髓源性巨噬细胞和Caco-2上皮细胞中不太明显。与诺考达唑和秋水仙碱相反，微管稳定药物紫杉醇对L。单核细胞增多症的所有三种细胞类型测试。(C)1998年，欧洲微生物学会联合会。出版社：Elsevier Science B. V.
Uptake of Listeria monocytogenes by different mammalian cells like macrophages and epithelial cells is dependent on functional actin filaments and hence susceptible to inhibition by cytochalasin. Here we show that phagocytic uptake of L. monocytogenes by P388D(1) macrophages is also highly sensitive to treatment with the microtubule depolymerizing drugs nocodazole and colchicine. This sensitivity is cell type specific and much less pronounced in bone marrow-derived macrophages and Caco-2 epithelial cells. In contrast to nocodazole and colchicine, the microtubule stabilizing drug taxol has no significant effect on the uptake of L. monocytogenes by all three cell types tested. (C) 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V.