Roles of StearoylCoA Desaturase-1 in the Regulation of Cancer Cell Growth, Survival and Tumorigenesis.
Roles of StearoylCoA Desaturase-1 in the Regulation of Cancer Cell Growth, Survival and Tumorigenesis.
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DOI：
10.3390/cancers3022462
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发表时间：
2011-05-20
期刊：
影响因子：
5.2
通讯作者：
Igal RA
中科院分区：
文献类型：
--
作者：
Igal RA
癌症的定义特征的发展和维持，例如不间断的细胞增殖、逃避程序性细胞死亡以及定植局部组织和远处器官的能力，需要大量生产具有适当脂肪酸组成的结构、信号传导和能量储存脂质生物分子。由于脂肪酸生物合成的组成型激活，癌细胞脂质富含饱和脂肪酸 (SFA)，特别是单不饱和脂肪酸 (MUFA)，这些脂肪酸是由硬脂酰辅酶 A 去饱和酶-1（将 SFA 转化为 MUFA 的主要酶）产生的。越来越多的实验和流行病学研究表明，高水平的 SCD1 活性是建立有利于致癌过程的生化和代谢扰动的主要因素。本综述检查了证据，表明 SCD1 在调节多种生物机制中具有重要意义，特别是脂质生物合成以及有助于癌症发生和进展的增殖和生存信号通路。
The development and maintenance of defining features of cancer, such as unremitting cell proliferation, evasion of programmed cell death, and the capacity for colonizing local tissues and distant organs, demand a massive production of structural, signaling and energy-storing lipid biomolecules of appropriate fatty acid composition. Due to constitutive activation of fatty acid biosynthesis, cancer cell lipids are enriched with saturated (SFA) and, in particular, monounsaturated fatty acids (MUFA), which are generated by StearoylCoA desaturase-1, the main enzyme that transforms SFA into MUFA. An increasing number of experimental and epidemiological studies suggest that high levels of SCD1 activity is a major factor in establishing the biochemical and metabolic perturbations that favors the oncogenic process. This review examines evidence that suggests the critical implication of SCD1 in the modulation of multiple biological mechanisms, specifically lipid biosynthesis and proliferation and survival signaling pathways that contribute to the development and progression of cancer.