Competitive and cooperative metabolic interactions in bacterial communities
Competitive and cooperative metabolic interactions in bacterial communities
复制标题
DOI：
10.1038/ncomms1597
复制
发表时间：
2011-12-01
影响因子：
16.6
通讯作者：
Ruppin, Eytan
中科院分区：
文献类型：
--
作者：
Freilich, Shiri;Zarecki, Raphy;Ruppin, Eytan
揭示塑造群落的生态学原理是后基因组时代的一个重大挑战。迄今为止，一直缺乏一个系统的方法来描述物种间的相互作用。在这里，我们独立地预测了来自118个物种的代谢模型集合的6，903个细菌对之间的竞争和合作潜力。我们图表之间的竞争与合作表明，合作潜力最大化在适度的资源重叠水平的复杂关联。利用来自2，801个样本的生态数据，我们探索了细菌相互作用和共存模式之间的关联。高水平的竞争与相互排他性的分配模式的物种之间观察到的支持竞争在社区组装的作用。合作互动通常是单向的，对给予者没有明显的好处。然而，在它们的自然群落中，细菌通常形成紧密的合作循环，从而间接造福于所有相关物种。这些研究结果是重要的，未来的设计财团优化生物修复和生物生产应用。
Revealing the ecological principles that shape communities is a major challenge of the post-genomic era. To date, a systematic approach for describing inter-species interactions has been lacking. Here we independently predict the competitive and cooperative potential between 6,903 bacterial pairs derived from a collection of 118 species' metabolic models. We chart an intricate association between competition and cooperation indicating that the cooperative potential is maximized at moderate levels of resource overlap. Utilizing ecological data from 2,801 samples, we explore the associations between bacterial interactions and coexistence patterns. The high level of competition observed between species with mutual-exclusive distribution patterns supports the role of competition in community assembly. Cooperative interactions are typically unidirectional with no obvious benefit to the giver. However, within their natural communities, bacteria typically form close cooperative loops resulting in indirect benefit to all species involved. These findings are important for the future design of consortia optimized towards bioremediation and bio-production applications.