Incidence Rate of Cardiovascular Disease End Points in the National Aeronautics and Space Administration Astronaut Corps
Incidence Rate of Cardiovascular Disease End Points in the National Aeronautics and Space Administration Astronaut Corps
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DOI：
10.1161/jaha.117.005564
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发表时间：
2017-08-01
影响因子：
5.4
通讯作者：
Barstow, Thomas J.
中科院分区：
文献类型：
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作者：
Ade, Carl J.;Broxterman, Ryan M.;Barstow, Thomas J.
背景-宇航员职业或暴露于微重力环境是否会影响长期心血管疾病（CVD）的风险尚不清楚。本研究探讨了作为一个职业的美国国家航空航天局（NASA）的宇航员对临床心血管疾病endpoints.Methods和Results的风险的影响，在纵向研究的宇航员健康，数据收集了310名美国宇航局宇航员和981 nonastronaut美国宇航局雇员。非宇航员与宇航员在年龄、性别和体重指数上相匹配，以评估急性和慢性发病率和死亡率。主要结局是临床CVD终点（心肌梗死、充血性心力衰竭、卒中和冠状动脉搭桥术）或冠状动脉疾病（CAD）终点（心肌梗死和冠状动脉搭桥术）的复合终点。在宇航员中，5.2%有临床CVD终点，2.9%有CAD终点，而非宇航员的CVD和CAD终点分别为4.7%和3.1%。在校正传统危险因素的多变量模型中，宇航员与非宇航员相比，CVD的风险相似（校正后的风险比，1.08; 95%CI，0.60-1.93; P=0.80）。两组之间的CAD终点风险相似（风险比，0.97; CI，0.45-2.08; P=0.93）。在宇航员与早期航天经验，心血管疾病（风险比，0.80; CI，0.25-2.56; P=0.71）和CAD（风险比，1.23; CI：0.27-5.61; P=0.79）的风险与宇航员相比，没有experience. Conclusions这些研究结果表明，作为一名宇航员是不相关的心血管疾病的发展增加的长期风险。
Background-It is unknown whether the astronaut occupation or exposure to microgravity influences the risk of long-term cardiovascular disease (CVD). This study explored the effects of being a career National Aeronautics and Space Administration (NASA) astronaut on the risk for clinical CVD end points.Methods and Results-During the Longitudinal Study of Astronaut Health, data were collected on 310 NASA astronauts and 981 nonastronaut NASA employees. The nonastronauts were matched to the astronauts on age, sex, and body mass index, to evaluate acute and chronic morbidity and mortality. The primary outcomes were composites of clinical CVD end points (myocardial infarction, congestive heart failure, stroke, and coronary artery bypass surgery) or coronary artery disease (CAD) end points (myocardial infarction and coronary artery bypass surgery). Of the astronauts, 5.2% had a clinical CVD end point and 2.9% had a CAD end point compared with the nonastronaut comparisons with 4.7% and 3.1% having CVD and CAD end points, respectively. In the multivariate models adjusted for traditional risk factors, astronauts had a similar risk of CVD compared with nonastronauts (adjusted hazard ratio, 1.08; 95% CI, 0.60-1.93; P=0.80). Risk of a CAD end point was similar between groups (hazard ratio, 0.97; CI, 0.45-2.08; P=0.93). In astronauts with early spaceflight experience, the risk of CVD (hazard ratio, 0.80; CI, 0.25-2.56; P=0.71) and CAD (hazard ratio, 1.23; CI: 0.27-5.61; P=0.79) compared with astronauts with no experience were not different.Conclusions-These findings suggest that being an astronaut is not associated with increased long-term risk of CVD development.