Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan
Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan
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DOI：
10.1016/j.chemosphere.2006.05.010
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发表时间：
2007-01-01
期刊：
影响因子：
8.8
通讯作者：
Ikeda, Masayuki
中科院分区：
文献类型：
--
作者：
Harada, Kouji;Koizumi, Akio;Ikeda, Masayuki
由于全氟辛烷磺酸（PFOS）和全氟辛酸盐（PFOA）在环境以及野生动物和人类中的广泛污染，它们最近受到了关注。我们测量了在京都收集的20至59岁的历史记录人类血清样本中的PFOS和PFOA浓度，每个时间点20人（n = 100），以及在日本10个地点收集的20至59岁的人类血清样本中的PFOS和PFOA浓度（n = 200）。1983 - 1999年收集的历史样本表明，京都地区男性和女性的PFOA浓度分别以0.49 ng/ml/年和0.42 ng/ml/年的速度增长了4.4倍和4.3倍。相比之下，全氟辛烷磺酸的血清浓度在20世纪80年代末达到了一个平稳期。全氟辛烷磺酸和全氟辛烷磺酸的血清浓度也存在地区差异。2003-2004年，全氟辛烷磺酸和全氟辛烷磺酸的血清浓度[几何平均（几何标准差）]（ng/ml）在福井县松冈镇为7.6（1.6）至京都市为27.8(1.6)，在松冈市为2.3（1.5）至大阪市为14.5（1.3）。(c) 2006 Elsevier Ltd.版权所有。
Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) have recently received attention due to their widespread contamination in the environment, as well as in wildlife and humans. We measured the PFOS and PFOA concentrations in historically recorded human serum samples at an age range between 20 and 59 years collected in Kyoto, 20 persons per each time point (n = 100), and also the PFOS and PFOA concentrations in human serum samples at an age range between 20 and 59 years from 10 locations throughout Japan (n = 200). The historical samples collected from 1983 to 1999 demonstrated that the PFOA concentrations in males and females from Kyoto have increased 4.4-fold and 4.3-fold at a rate of increase of 0.49 ng/ml/year and 0.42 ng/ml/year, respectively. In contrast, serum concentrations of PFOS reached a plateau in the late 1980s. There are also regional differences in both the PFOS and PFOA serum concentrations. The concentrations in serum [geometric mean (geometric standard deviation)] (ng/ml) in 2003-2004 ranged from 7.6(1.6) in the town of Matsuoka in Fukui prefecture to 27.8(1.6) in Kyoto city, and ranged from 2.3(1.5) in Matsuoka to 14.5(1.3) in Osaka city for PFOS and PFOA, respectively. (c) 2006 Elsevier Ltd. All rights reserved.