Flunisolide decreases exhaled nitric oxide and nitrotyrosine levels in asthmatic children
Flunisolide decreases exhaled nitric oxide and nitrotyrosine levels in asthmatic children
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DOI：
10.1155/mi/2006/31919
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发表时间：
2006-01-01
影响因子：
4.6
通讯作者：
Piacentini, G. L.
中科院分区：
文献类型：
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作者：
Bodini, A.;Peroni, D. G.;Piacentini, G. L.
背景据报道，呼出的一氧化氮（FeNO）在涉及哮喘患者的氧化应激中升高，并且一氧化氮（NO）与超氧阴离子反应导致硝基酪氨酸的形成。本研究的目的是研究吸入性类固醇治疗对呼出气冷凝液（EBC）收集的硝基酪氨酸水平和FeNO的影响。方法.这是一项单盲安慰剂对照研究。对10例哮喘患儿进行肺功能、FeNO和硝基酪氨酸水平测定。结果安慰剂期间硝基酪氨酸水平稳定（T0 = 1.16 ng/ml vs T1 = 1.05 ng/ml; NS），而氟尼缩松治疗后则下降（T2 = 1.14 ng/ml对T3 = 0.88 ng/ml; P <0.001）。安慰剂治疗后未观察到FeNO水平显著降低（T0 = 38.4 ppb vs T1 = 34.7 ppb，NS）。相比之下，FeNO值在T3 = 14.9 ppb时显著降低（T1 vs T3; P = 0.024）。结论.这项研究表明，皮质类固醇治疗降低哮喘受试者EBC中的硝基酪氨酸水平。版权所有（c）2006 A. Bodini等人
Background. Exhaled nitric oxide (FeNO) has been reported to be elevated in the oxidative stress involved in asthmatic patients, and the reaction of nitric oxide ( NO) with superoxide anions results in the formation of nitrotyrosine. The purpose of this study was to investigate the effect of inhaled steroid treatment on nitrotyrosine levels collected by exhaled breath condensate (EBC) and on FeNO. Methods. This was a single-blind placebo-controlled study. The lung function, FeNO, and nitrotyrosine levels were evaluated in 10 asthmatic children. Results. The nitrotyrosine levels were stable during the placebo period (T0 = 1.16 ng/ml versus T1 = 1.05 ng/ml; NS.), whereas they decreased after the treatment with flunisolide (T2 = 1.14 ng/ml versus T3 = 0.88 ng/ml; P < .001). No significant reduction in FeNO levels was observed after placebo treatment (T0 = 38.4 ppb versus T1 = 34.7 ppb, NS.). In contrast, FeNO values decreased significantly being at T3 = 14.9 ppb (T1 versus T3; P = .024). Conclusions. This study shows that corticosteroid treatment reduces nitrotyrosine levels in EBC of asthmatic subjects. Copyright (c) 2006 A. Bodini et al.