THE FETAL ALCOHOL SYNDROME IN MICE - MATERNAL VARIABLES
THE FETAL ALCOHOL SYNDROME IN MICE - MATERNAL VARIABLES
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DOI：
10.1002/tera.1420220110
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发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
CHERNOFF, GF
中科院分区：
文献类型：
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作者：
CHERNOFF, GF
CBA， C3H和C57雌性小鼠在妊娠前和妊娠期间保持20%乙醇来源卡路里的饮食，进行双等位杂交。产前死亡、畸形和胎儿体重与母亲血液中的酒精含量直接相关，表明母亲的影响。胎儿异常和母亲血液酒精水平随母株（CBA > C3H > C57）而变化，并与母亲酒精脱氢酶活性呈负相关。微粒体乙醇氧化系统的诱导与胎儿畸形的增加直接相关，在CBA女性中最为明显。显然，这种综合征的畸形模式的责任取决于母亲血液中的酒精含量，这是由母亲酒精代谢率和母亲酒精消费量决定的。
CBA, C3H and C57 female mice maintained on a diet of 20% ethanol-derived calories prior to and throughout gestation were mated in a diallele cross. Prenatal death, malformations and fetal weights were directly related to maternal blood alcohol levels, indicating a maternal effect. Fetal abnormalities and maternal blood alcohol levels varied with maternal strain (CBA > C3H > C57) and were inversely related to maternal alcohol dehydrogenase activity. Microsomal ethanol oxidizing systems induction was directly associated with increased fetal abnormalities, being greatest in CBA females. Apparently, liability for the pattern of malformation in this syndrome is dependent on maternal blood alcohol levels, which are determined by the rate of maternal alcohol metabolism and the amount of maternal alcohol consumption.