The trajectory of IGF-1 across age and duration of type 1 diabetes.
The trajectory of IGF-1 across age and duration of type 1 diabetes.
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IGF-1 随年龄和 1 型糖尿病病程的变化轨迹。
DOI：
10.1002/dmrr.2554
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Danielson,KirstieK
中科院分区：
文献类型：
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作者：
Palta,Mari;LeCaire,TamaraJ;Sadek-Badawi,Mona;Herrera,VictorM;Danielson,KirstieK
背景：1型糖尿病患者的IGF‐1水平可能较低，这与胰岛素缺乏和胰岛素抵抗有关。很少有关于IGF - 1水平的纵向研究，以确定其在1型糖尿病中与病程和年龄有关的模式，并检查IGF - 1是否随时间在个体中追踪。我们研究了年龄和持续时间的趋势，以及IGF - 1与性别、血糖控制、胰岛素水平和其他因素的关系。威斯康星糖尿病登记研究（Wisconsin Diabetes Registry Study）是一项针对1987年5月至1992年4月诊断为1型糖尿病的事件队列研究，该研究对参与者进行了长达18年的IGF - 1样本随访，女性至45岁，男性至37岁。结果1型糖尿病患者的igf - 1水平低于正常人群。尽管，不同年龄的模式与标准样本相似，青春期达到峰值，20岁后缓慢下降，但1型糖尿病女性的青春期峰值延迟。IGF - 1在个体中有低到中度的追踪。较高的胰岛素剂量与较高的IGF - 1、青春期和女性性别相关。对这些因素进行调整后，IGF - 1在糖尿病早期病程中迅速下降。在Tanner 1期和2期，较低的HbA1c与较高的IGF - 1密切相关。结论sigf - 1在1型糖尿病患者中较低，在女性中出现延迟的青春期高峰，并且特别受早期和青春期前血糖控制的影响。个体内部的高度变异性可能是研究IGF - 1与长期结果之间关系的挑战，并可能解释矛盾的发现。版权所有©2014 John Wiley & Sons， Ltd。
BackgroundIndividuals with type 1 diabetes may have low IGF‐1, related to insulinopenia and insulin resistance. There are few longitudinal studies of IGF‐1 levels to establish its pattern in type 1 diabetes with duration and age, and to examine whether IGF‐1 tracks within individuals over time. We examine age and duration trends, and the relationship of IGF‐1 to gender, glycaemic control, insulin level and other factors.MethodsParticipants in the Wisconsin Diabetes Registry Study, an incident cohort study of type 1 diabetes diagnosed May 1987–April 1992, were followed for up to 18 years with IGF‐1 samples up to age 45 for women and age 37 for men.ResultsIGF‐1 is lower with type 1 diabetes than in normative samples. Although, the pattern across age resembles that in normative samples with a peak in adolescence and slow decline after age 20, the adolescent peak is delayed for women with type 1 diabetes. There was low to moderate tracking of IGF‐1 within an individual. Higher insulin dose was associated with higher IGF‐1 as was puberty, and female gender. Adjusted for these factors, IGF‐1 declined rapidly across early diabetes duration. Lower HbA1c was most strongly related to higher IGF‐1 at Tanner stages 1 and 2.ConclusionsIGF‐1 is low in type 1 diabetes, with a delayed adolescent peak in women and is especially influenced by glycaemic control in early and pre‐adolescence. High variability within an individual is likely a challenge in investigating associations between IGF‐1 and long‐term outcomes, and may explain contradictory findings. Copyright © 2014 John Wiley & Sons, Ltd.