Tracking the epidemiology of human genes in the literature: The HuGE Published Literature database
Tracking the epidemiology of human genes in the literature: The HuGE Published Literature database
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DOI：
10.1093/aje/kwj175
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发表时间：
2006-07-01
影响因子：
5
通讯作者：
Khoury, Muin J.
中科院分区：
文献类型：
--
作者：
Lin, Bruce K.;Clyne, Melinda;Khoury, Muin J.
人类基因组测序的完成激发了对基因变异的流行及其与人类疾病之间关系的新一轮流行病学研究。2001年，人类基因组流行病学（HuGE）网络推出了HuGE已发表文献数据库（HuGE Pub Lit），这是一个可搜索的在线知识库，包含已发表的、基于人群的人类基因流行病学研究。该数据库包含PubMed文章的链接，可以通过基因、疾病、相互作用因素、研究设计或分析类型或这些类别中的任何术语组合进行搜索。检索输出包含到每一篇识别文章的链接，沿着一个总结报告研究关键特征的表格。截至2005年9月6日，约17，665篇文章被编入数据库。大多数人描述了基因-疾病关联（86%）;较少评估基因-基因或基因-环境相互作用（17%），基因变异的患病率（10%）或基因检测（3%）。虽然不全面，这个数据库是一个独特的工具，流行病学研究人员和其他有关的作用，遗传变异在人口健康。在这里，作者提供了数据库及其特性和用途的概述。
Completion of the human genome sequence has inspired a new wave of epidemiologic studies on the prevalence of gene variants and their associations with diseases in human populations. In 2001, the Human Genome Epidemiology (HuGE) Network launched the HuGE Published Literature database (HuGE Pub Lit), a searchable, online knowledge base of published, population-based epidemiologic studies of human genes. The database contains links to PubMed articles and can be searched by gene, disease, interacting factor, type of study design or analysis, or any combination of terms in these categories. The search output contains a link to each identified article, along with a table summarizing key features of the reported study. As of September 6, 2005, some 17,665 articles were indexed in the database. Most described gene-disease associations (86%); fewer evaluated gene-gene or gene-environment interactions (17%), the prevalence of gene variants (10%), or genetic tests (3%). Although not comprehensive, this database is a unique tool for epidemiologic researchers and others concerned with the role of genetic variation in population health. Here, the authors provide an overview of the database and its characteristics and uses.