Vasopressin facilitates play fighting in juvenile golden hamsters
Vasopressin facilitates play fighting in juvenile golden hamsters
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DOI：
10.1016/j.physbeh.2009.04.019
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发表时间：
2009-08-04
影响因子：
2.9
通讯作者：
Delville, Yvon
中科院分区：
文献类型：
--
作者：
Cheng, Shao-Ying;Delville, Yvon
加压素促进成年仓鼠的攻击性。这种神经肽在打斗中是否有类似的作用还不清楚。本研究的目的是确定是否加压素控制发挥战斗的青少年金仓鼠以及。少年雄性金仓鼠进行了测试后，微量注射加压素V1A受体拮抗剂，曼宁化合物，无论是0，9，或90 μ M，到前下丘脑玩战斗。这种治疗选择性地抑制了实验动物在游戏中打斗的攻击性方面。两种剂量的曼宁化合物均显著降低了发作频率。此外，高剂量的受体拮抗剂增加了攻击潜伏期，减少了叮咬频率，并减少了每次接触回合的平均攻击次数。总之，这些结果表明，加压素控制整个发展过程中的攻击性行为，从青少年的玩耍战斗到成年人的攻击性。(C)2009 Elsevier Inc. All rights reserved.
Vasopressin facilitates aggression in adult hamsters. Whether this neuropeptide has a similar role in play fighting remains unknown. The goal of the present study was to identify whether vasopressin controls play fighting in juvenile golden hamsters as well. Juvenile male golden hamsters were tested for play fighting after microinjections of a vasopressin V1A-receptor antagonist, Manning compound, either 0, 9, or 90 mu M, into the anterior hypothalamus. The treatment selectively inhibited offensive aspects of play fighting in experimental animals. Attack frequencies were significantly decreased by both doses of Manning compound. In addition, the high dose of the receptor antagonist increased attack latencies, decreased bite frequencies, and decreased the averaged number of attacks per contact bout. Together, these results show that vasopressin controls offensive behaviors throughout development from play fighting in juveniles to aggression in adults. (C) 2009 Elsevier Inc. All rights reserved.