Utility of a modified version of the wisconsin card sorting test in the detection of dementia of the alzheimer type.
Utility of a modified version of the wisconsin card sorting test in the detection of dementia of the alzheimer type.
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DOI：
10.1080/13854049308401518
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发表时间：
1993-04-01
期刊：
影响因子：
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通讯作者：
Paulsen, Jane S
中科院分区：
文献类型：
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作者：
Bondi, Mark W;Monsch, Andreas U;Paulsen, Jane S
采用纳尔逊（1976）改良版威斯康星州卡片分类测验（mWCST）对23例轻度阿尔茨海默型痴呆（DAT）患者、33例中度DAT患者、31例重度DAT患者和75例人口统计学匹配的正常对照（NC）受试者进行测试。DAT患者达到更少的类别，并承诺比NC科目的持续性错误。DAT患者亚组在持续性错误的数量上没有差异，但重度DAT患者获得的类别明显少于轻度或中度DAT患者。绘制了受试者操作特征[ROC]曲线，以确定几种测量方法中哪一种提供了最佳灵敏度（即，正确识别的患者）和特异性（即，正确识别的正常对照）。达到的类别的数量被认为是最好的判别措施，为整个样本的DAT患者，而持续错误的数量提供了最好的区分度在轻度DAT患者。研究结果表明，纳尔逊的原始修改的WCST是敏感的早期检测DAT。
Nelson's (1976) modified version of the Wisconsin Card Sorting Test (mWCST) was administered to 23 patients with mild dementia of the Alzheimer type (DAT), 33 moderate DAT patients, 31 severe DAT patients, and 75 demographically matched normal control (NC) subjects. DAT patients attained fewer categories and committed significantly more perseverative errors than NC subjects. None of the DAT patient subgroups differed in the number of perseverative errors committed, but the severe DAT patients attained significantly fewer categories than either the mild or moderate DAT patients. Receiver operating characteristic [ROC] curves were plotted to determine which among several of the measures provided the best sensitivity (i.e., correctly identified patients) and specificity (i.e., correctly identified normal controls). The number of categories attained was found to be the best discriminative measure for the entire sample of DAT patients, whereas the number of perseverative errors provided the best discriminability in mild DAT patients. Findings suggest that Nelson's original modification of the WCST is sensitive in the early detection of DAT.