Regulatory pattern identification in nucleic acid sequences.
Regulatory pattern identification in nucleic acid sequences.
复制标题
核酸序列中的调控模式识别。
DOI：
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发表时间：
1983
影响因子：
14.9
通讯作者：
Temple F. Smith
中科院分区：
文献类型：
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作者：
J. Sadler;Michael S. Waterman;Temple F. Smith
除了在众多的基因序列中识别出的序列同源性和统计模式之外，还有一些更微妙的模式类别，对于这些模式，大多数当前的计算机搜索方法提供的实用性非常有限。这一类包括各种假定的真核生物调控位点。经常采用的共识和局部同源性的方法的批评表明，需要新的工具。特别是，这些新方法应该使用现在可以获得的位置和结构数据，这些数据可以准确地确定序列特异性结合蛋白在DNA序列中识别的是什么。
In addition to the sequence homologies and statistical patterns identified among numerous genetic sequences, there are subtler classes of patterns for which most current computer search methods offer very limited utility. This class includes various presumptive eukaryotic regulatory sites. A critique of the often employed consensus and local homology methods suggests the need for new tools. In particular, such new methods should use the positional and structural data now becoming available on exactly what it is that is recognized in the DNA sequence by sequence-specific binding proteins.