Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease
Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease
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DOI：
10.1093/brain/awm107
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发表时间：
2007-07-01
期刊：
影响因子：
14.5
通讯作者：
Paulsen, Jane S.
中科院分区：
文献类型：
--
作者：
Johnson, Shannon A.;Stout, Julie C.;Paulsen, Jane S.
先前的情绪识别研究表明，厌恶的检测依赖于基底神经节和小脑的处理。对患有症状性和诊断前的亨廷顿病（HD）（一种已知伴有基底神经节萎缩的疾病）的个体的研究通常表明，在识别厌恶方面存在相对障碍。然而，一些数据表明，其他情绪（特别是恐惧和愤怒）的识别也可能受到HD的影响，最近的一项研究发现，在没有其他情绪识别障碍的情况下，恐惧识别缺陷，包括厌恶。为了进一步研究HD的情绪识别，我们对475名HD CAG扩展的个体和57名没有扩展的个体进行了计算机化的面部情绪识别任务。Logistic回归用于检查情绪识别性能与估计接近临床诊断（基于CAG重复序列长度和当前年龄）和纹状体体积的关联。对愤怒、厌恶、恐惧、悲伤和惊讶（但不是快乐）的识别与临床诊断的估计年数有关;表现与纹状体体积无关。与CAG正常对照组相比，CAG扩展组对所有负面情绪（愤怒，厌恶，恐惧，悲伤）的识别准确性显着降低。此外，具有更明显的HD运动体征的参与者在识别负面情绪方面的准确性明显低于运动体征较少的人。研究结果表明，在疾病过程的早期，对所有负面情绪的识别都会下降，而较差的表现与更接近临床诊断有关。与之前的结果相反，我们没有发现在识别厌恶或恐惧方面存在相对障碍的证据，也没有证据支持纹状体和厌恶识别之间的联系。
Previous studies of emotion recognition suggest that detection of disgust relies on processing within the basal ganglia and insula. Research involving individuals with symptomatic and pre-diagnostic Huntington's disease (HD), a disease with known basal ganglia atrophy, has generally indicated a relative impairment in recognizing disgust. However, some data have suggested that recognition of other emotions (particularly fear and anger) may also be affected in HD, and a recent study found fear recognition deficits in the absence of other emotion-recognition impairments, including disgust. To further examine emotion recognition in HD, we administered a computerized facial emotion recognition task to 475 individuals with the HD CAG expansion and 57 individuals without. Logistic regression was used to examine associations of emotion recognition performance with estimated proximity to clinical diagnosis (based on CAG repeat length and current age) and striatal volumes. Recognition of anger, disgust, fear, sadness and surprise (but not happiness) was associated with estimated years to clinical diagnosis; performance was unrelated to striatal volumes. Compared to a CAG-normal control group, the CAG-expanded group demonstrated significantly less accurate recognition of all negative emotions (anger, disgust, fear, sadness). Additionally, participants with more pronounced motor signs of HD were significantly less accurate at recognizing negative emotions than were individuals with fewer motor signs. Findings indicate that recognition of all negative emotions declines early in the disease process, and poorer performance is associated with closer proximity to clinical diagnosis. In contrast to previous results, we found no evidence of relative impairments in recognizing disgust or fear, and no evidence to support a link between the striatum and disgust recognition.