Pharmacotherapy of post-traumatic stress disorder: a family practitioners guide to management of the disease.
Pharmacotherapy of post-traumatic stress disorder: a family practitioners guide to management of the disease.
复制标题
DOI：
10.1586/14737175.5.1.129
复制
发表时间：
2005-01-01
影响因子：
4.3
通讯作者：
McBride, Joanna C
中科院分区：
文献类型：
--
作者：
Katzman, Martin A;Struzik, Lukasz;McBride, Joanna C
创伤后应激障碍很难治疗但常见的疾病，这与大量发病率，死亡率和社会负担有关。创伤后应激障碍的全面管理必须包括心理治疗和药理成分。当前基于证据的药物管理方法用于创伤后应激障碍，表明单一治疗的一线治疗方法是选择性5-羟色胺再摄取抑制剂，舍曲林，帕罗西汀和氟西汀。其他潜在的选择包括其他单层治疗，包括Venlafaxine，Mirtazapine，三环类抗抑郁药，单胺氧化酶抑制剂，以及非典型抗精神病药，Lamotrigine，Trazadone，Trazadone和许多肾上腺素剂的辅助用法。治疗的试验应至少为8周，并且至少要在至少12个月内持续，但可能会更长。鉴于未经治疗的创伤后应激障碍（例如自杀和心理社会功能受损）的风险，可能需要持续2年或更长时间。在急性心理创伤时进行的药物治疗在将来预防创伤后应激障碍有望进一步研究。
Post-traumatic stress disorder is a difficult to treat, yet common disorder, which is associated with significant morbidity, mortality and societal burden. Comprehensive management of post-traumatic stress disorder must include both psychotherapeutic and pharmacologic components. The current evidence-based pharmacologic management approaches to post-traumatic stress disorder, suggests that first-line treatments for monotherapy are the selective serotonin reuptake inhibitors, sertraline, paroxetine and fluoxetine. Other potential options include other monotherapies including venlafaxine, mirtazapine, tricyclic antidepressants, monoamine oxidase inhibitors, as well as adjunctive usage of atypical antipsychotics, lamotrigine, trazadone and a number of adrenergic agents. A trial of therapy should be at least 8 weeks and continue for at the very least 12 months, but is likely to be much longer. In light of the risks of untreated post-traumatic stress disorder (e.g., suicide and impaired psychosocial functioning), therapy may need to be continued for 2 years or more. Pharmacologic therapy instituted at the time of acute psychologic trauma shows promise for the prevention of post-traumatic stress disorder in the future and warrants further study.