Flavonoids from Dalbergia louvelii and their antiplasmodial activity
Flavonoids from Dalbergia louvelii and their antiplasmodial activity
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DOI：
10.1021/np030008x
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发表时间：
2003-11-01
影响因子：
5.1
通讯作者：
Frappier, F
中科院分区：
文献类型：
--
作者：
Beldjoudi, N;Mambu, L;Frappier, F
从降香（Dalbergia louvelii）心材中分离得到4个新的黄酮类化合物（1-4），沿着分离得到13个已知化合物。在分离的化合物中，四种已知化合物显示出抗疟原虫活性，IC 50值范围为5.8至8.7 μ M，即（R）-4 ″-甲氧基黄檀酮（5）、钝黄呋喃（6）、7，4 ′-二羟基-3 ′-甲氧基黄檀酮（7）和异甘草素（8）。新化合物的结构经波谱分析分别确定为1-（3-羟基苯基）-3-（4-羟基-2，5-二甲氧基苯基）丙烷（1）、螺罗夫林（2）、（3R）-7，2 ′-二羟基-4 ′，5 ′-二甲氧基异黄烷酮（3）和3-（2，4-二羟基-5-甲氧基）苯基-7-羟基香豆素（4）。
Four new flavonoids (1-4), along with 13 known compounds, were isolated from the heartwood of Dalbergia louvelii by following their potential to inhibit in vitro the growth of Plasmodium falciparum. Of the isolated compounds, four known compounds showed antiplasmodial activity with IC50 values ranging from 5.8 to 8.7 muM, namely, (R)-4"-methoxydalbergione (5), obtusafuran (6), 7,4'-dihydroxy-3'-methoxyisoflavone (7), and isoliquiritigenin (8). The structures of the new compounds were determined using spectroscopic techniques as 1-(3-hydroxyphenyl)-3-(4-hydroxy-2,5-dimethoxyphenyl)propane (1), spirolouveline (2), (3R)-7,2'-dihydroxy-4',5'-dimethoxyisoflavanone (3), and 3-(2,4-dihydroxy-5-methoxy)phenyl-7-hydroxycoumarin (4), respectively.