Pathological features of rectal cancer after preoperative radiochemotherapy
Pathological features of rectal cancer after preoperative radiochemotherapy
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DOI：
10.1007/s003840050072
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发表时间：
1997-02-01
影响因子：
2.8
通讯作者：
Hoffmann, A
中科院分区：
文献类型：
--
作者：
Dworak, O;Keilholz, L;Hoffmann, A
直肠癌的标准治疗是手术，然而，术前放化疗将发挥越来越大的作用，特别是在局部晚期疾病中。为了估计放化疗的预后和效果，评估放化疗后的病理特征很重要。我们检查了 17 名患者术前放化疗后的手术标本，以评估和分级组织学反应。还描述了肿瘤消退分级系统的提案（文献中尚未提供）。除一种癌外，所有癌均显示出不同程度的肿瘤消退。标准化病理检查后未观察到完全消退。只有一种情况无法进行局部治愈性切除。我们认为术前放化疗能够减少肿瘤质量，从而在无法治愈手术的病例中实现可手术性。我们推荐病理检查和回归分级的标准，以便进一步研究比较直肠癌的手术和放化疗。
The standard therapy for rectal carcinoma is surgical, however, preoperative radiochemotherapy will play an increasing role especially in locally advanced disease. To estimate the prognosis and the effect of radiochemotherapy the postradiochemotherapeutical pathological features are important to assess. We examined the surgical specimens of 17 patients after preoperative radiochemotherapy to estimate and grade the histological reactions. A proposal for a grading system for tumor regression (not yet available in the literature) has also been described. All but one of the carcinomas showed different degrees of tumor regression. A total regression was not observed after standardised pathological work up. In only one case a locally curative resection was not possible. We think that preoperative radiochemotherapy is able to reduce tumor mass thus achieving operability in non-curatively operable cases. We recommend standards of pathological work up and regression grading for further studies comparing surgery and radiochemotherapy of rectal carcinoma.